AEEA-AEEA

AEEA-AEEA (Aminoethoxyethoxyacetate dimer)

Tsvagiridzo Yekushandisa:
AEEA-AEEA is hydrophilic, inochinjika spacer inowanzoshandiswa mu peptide uye zvinodhaka conjugation research. Inosanganisira maviri ethylene glycol-based units, zvichiita kuti zvive zvakakosha pakudzidza migumisiro ye linker kureba uye kushanduka pakubatana kwema molecular, solubility, uye biological chiitiko. Vatsvagiri vanowanzo shandisa zvikamu zveAEEA kuongorora kuti ma spacers anopesvedzera sei mashandiro eantibody-drug conjugates (ADCs), peptide-drug conjugates, uye mamwe bioconjugates.

Basa:
AEEA-AEEA inoshanda senge biocompatible linker inowedzera solubility, inoderedza steric chipingamupinyi, uye inovandudza kushanduka kwema molecular. Inobatsira kupatsanura matunhu anoshanda mukati memorekuru, senge kunanga ligands uye mitoro yekubhadhara, ichibvumira kusungirira kwakanyatsoita uye chiitiko. Yayo isiri-immunogenic uye hydrophilic chimiro zvakare inobatsira pakuvandudza pharmacokinetic profiles mukurapa kwekushandisa.