Donilorsen

Donilorsen (API)

Tsvagiridzo Yekushandisa:
Donidalorsen API is an antisense oligonucleotide (ASO) iri pasi pekuferefeta kurapwa kwenhaka angioedema (HAE) uye ine hukama hwekuzvimba mamiriro. Inodzidzwa mumamiriro ezvinhu eRNA-inotarirwa marapirwo, nechinangwa chekudzikisa kutaura kweplasma prekallikrein(KLKB1 mRNA). Vatsvagiri vanoshandisa Donidalorsen kuti vatarise maitiro ekunyararidza majini, dosi-inotsamira pharmacokinetics, uye kudzora kwenguva refu kwebradykinin-mediated kuzvimba.

Basa:
Donidalorsen inoshanda nekusarudza kusunga kuneKLKB1mRNA, kuderedza kugadzirwa kwe plasma prekallikrein - yakakosha enzyme mu kallikrein-kinin system inokonzera kukonzera kuzvimba uye kuzvimba muHAE. Nekudzikisa mazinga e kallikrein, Donidalorsen inobatsira kudzivirira HAE kurwiswa uye kuderedza mutoro wechirwere. Se API, inoshanda sechinhu chakakosha chekurapa mukuvandudza kwekuita kwenguva refu, kurapwa kunoitwa nepasi peHAE.