Fitusiran

Fitusiran (API)

Tsvagiridzo Yekushandisa:
Fitusiran API ndeyekugadzira diki inopindira RNA (siRNA) yakaongororwa zvakanyanya mumunda wehemophilia uye coagulation kusagadzikana. Inonangana neantithrombin (AT kana SEPINC1)gene muchiropa kuderedza kugadzirwa kwe antithrombin. Vatsvakurudzi vanoshandisa Fitusiran kuongorora RNA interference (RNAi) nzira, chiropa-chaiyo gene kunyarara, uye novel nzira dzekurapa dzekugadzirisazve coagulation muhemophilia A uye B varwere, vane kana vasina inhibitors.

Basa:
Fitusiran inoshanda nekunyaradza kutaura kwe antithrombin, yakasikwa anticoagulant, nekudaro ichiwedzera thrombin chizvarwa uye kukurudzira kuumbwa kwegwamba. Iyi nzira inopa prophylactic kurapwa nzira yekudzikisa kubuda ropa muvarwere vehemophilia. Se API, Fitusiran inoshanda sechinhu chinoshanda mukurapa kwenguva refu-inobata subcutaneous therapies ine chinangwa chekuvandudza hupenyu uye kuderedza mutoro wekurapa mukubuda ropa kusagadzikana.