Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH

Tsvagiridzo Yekushandisa:
Fmoc-Thr(tBu)-Phe-OH idipeptide building block inowanzoshandiswa mune yakasimba-phase peptide synthesis (SPPS). Fmoc (9-fluorenylmethyloxycarbonyl) boka rinodzivirira N-terminus, nepo tBu (tert-butyl) boka rinodzivirira hydroxyl side chain yethreonine. Iyi dipeptide yakadzivirirwa inodzidzwa nezve basa rayo mukufambisa kwakaringana peptide kurebesa, kudzikisira kumhanya, uye kuenzanisira chaiyo inoteedzana modhi muchimiro cheprotein uye zvidzidzo zvekudyidzana.

Basa:
Fmoc-Thr (tBu) -Phe-OH inoshanda sechigadziro chekugadzira peptides inosanganisira threonine uye phenylalanine residues, iyo inokosha pakugadzira hydrogen bonds uye hydrophobic interactions. Iyo threonine parutivi cheni inopa polarity uye inogona kuita phosphorylation nzvimbo, nepo phenylalanine inowedzera inonhuhwirira hunhu uye kugadzikana kwechimiro. Musanganiswa uyu unobatsira mukugadzira mapeptide ezviyedzo zvebiological, zvidzidzo zvinosunga mareceptor, uye maapplication ekuwanikwa kwezvinodhaka.