Inclisiran sodium

Inclisiran Sodium (API)

Tsvagiridzo Yekushandisa:
Inclisiran sodium API (Active Pharmaceutical Ingredient) inodzidzwa kunyanya mumunda weRNA kupindira (RNAi) uye kurapa kwemwoyo. SeSiRNA ine tambo mbiri yakanangana nePCSK9 gene, inoshandiswa mu preclinical uye kiriniki yekutsvagisa kuongorora maitiro-akareba-anoita gene-kunyarara nzira dzekudzikisa LDL-C (yakaderera-density lipoprotein cholesterol). Iyo inoshandawo semuenzaniso wekomboni yekuongorora siRNA yekuendesa masisitimu, kugadzikana, uye chiropa-yakanangwa RNA therapeutics.

Basa:
Inclisiran sodium API inoshanda nekunyaradza PCSK9 gene muhepatocytes, zvichiita kuti kuderera kwekugadzirwa kwePCSK9 protein. Izvi zvinoguma nekuwedzeredzwa kudzokororwa kweLDL receptors uye kucheneswa kukuru kweLDL cholesterol kubva muropa. Basa rayo seyakareba-inobata cholesterol-inoderedza mumiririri inotsigira kushandiswa kwayo mukurapa hypercholesterolemia uye kuderedza dambudziko rehutano hwemwoyo. Se API, inoumba iyo yepakati inoshanda chikamu muInclisiran-based drug formulations.