Melanotan II

Purogiramu inonzi Melanotan II

Melanotan IIis a synthetic cyclic heptapeptide analog yeα-melanocyte-stimulating hormone (α-MSH), kugadzirwa kukukurudzira melanogenesis, kuwedzeraKudzivirira UV, uye modulatezvepabonde uye metabolic mabasa. Inoita seaasiri-anosarudza agonistye melanocortin receptors, kunyanyaMC1R, MC3R,uyeMC4R.

Pakutanga akadzidza nokuda kwayokutsvukauyephotoprotectivezvivakwa, Melanotan II yakaratidzawo mhedzisiro pakuwedzera libido, kudzvinyirirwa kwe appetite,uyesimba kuenzanisa, zvichiita kuti ive yakawanda-inoshanda yekutsvagisa peptide ine kufarira dermatology, endocrinology, uye mushonga wepabonde.

Nzira Yekuita

Melanotan II inoshanda nekuita akati wandei melanocortin receptors:

• MC1R: Zvinokurudzirakugadzirwa kwe melanin→ inowedzera ruvara rweganda uye kuchengetedzwa kweUV

• MC3R / MC4R: Inobatanidzwaappetite control, kuwedzera libido,uyesimba homeostasis

• Inoyambuka chipingamupinyi cheropa-uropi, inokonzera central neurohormonal pathways

Tsvagiridzo uye Zvingangoitwa Zvikumbiro

Kunyangwe isingatenderwe kushandiswa kwekurapa, Melanotan II inodzidzwa zvakanyanya kune zvinotevera:

1. Ganda Pigmentation uye UV Dziviriro

• Anosimudziraeumelanin synthesis, zvichitungamirira kukutsvuka kwepanyama

• Inopaphoto-protective effectspasina kubuda kwezuva

• Inogona kudzikisa njodzi yegomarara reganda muvanhu vane ganda rakanaka

2. Kusashanda zvakanaka kwepabonde

• Kuratidzwa kukuwedzera libido uye kukwezva zvepabondemuvarume nevakadzi

• Akadzidza seanogona kurapa kwekusagadzikana kwe erectile (ED)kuburikidza neMC4R activation

3. Appetite & Weight Management

• Chivabvukuderedza kudya uye kudya kudyanekuita pane hypothalamic pathways

• Inogona adjunct intsvakurudzo yekufutisa

API Zvimiro (neGentolex Boka)

• Kuchena kwepamusoro ≥ 99%(HPLC & LC-MS yakasimbiswa)

• Synthesized viasolid-phase peptide synthesis (SPPS)

• Yakaderera endotoxin, yakaderera yakasara zvinonyungudutsa

• Inowanikwa muR&D kune chiyero chekutengeserana