MOTS-C

Tsanangudzo Pfupi

MOTS-C API inogadzirwa pasi pemamiriro akasimba eGMP-akafanana nekushandisa solid phase peptide synthesis (SPPS) tekinoroji kuve nechokwadi chemhando yepamusoro, kuchena kwepamusoro uye kugadzikana kwepamusoro kwekutsvaga uye kushandiswa kwekurapa.
Product Features:

Kuchena ≥ 99% (yakasimbiswa neHPLC uye LC-MS),
Yakaderera endotoxin uye yakasara solvent yemukati,
Yakagadzirwa zvinoenderana neICH Q7 uye GMP-senge maprotocol,
Inogona kuwana kugadzirwa kwakakura, kubva pamilligram-level R&D batches kusvika giramu-level uye kilogram-level yekutengesa kushambadzira.

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Product Detail

Product Tags

Purogiramu inonzi MOTS-C

MOTS-C(Mitochondrial Open Reading Frame ye12S rRNA Type-c) ndeye 16-amino acid.mitochondria-derived peptide (MDP)yakavharwa neiyo mitochondrial genome. Kusiyana nechinyakare chenyukireya-encoded peptides, MOTS-c inobva ku12S rRNA dunhu remitochondrial DNA uye inoita basa rakakoshakudzora cellular metabolism, mhinduro yekushushikana, uye insulin senitivity.

Seinoveli yekurapa peptide,Purogiramu inonzi MOTS-cakawana kufarira kwakanyanya muminda yemetabolic kusagadzikana, kuchembera, kurovedza muviri physiology, uye mitochondrial mushonga. Iyo peptide parizvino iri pasi pekuferefetwa kwakanyanya uye inoonekwa semumiriri anovimbisachizvarwa chinotevera peptide therapeuticskunanga hutano hwemetabolism uye hupenyu hurefu.

Nzira Yekuita

MOTS-c inoita mhedzisiro yayo kuburikidzamitochondrial-nuclear cross-talk-Iyo nzira iyo mitochondria inotaurirana neiyo nucleus kuchengetedza cellular homeostasis. Iyo peptide inotamiswa kubva ku mitochondria kuenda kunucleus mukupindura kushushikana kwemetabolism, kwainoita sengemetabolic regulatornekupesvedzera gene expression.

Nzira dzakakosha dzebhayoloji dzinosanganisira:

Kuitwa kweAMPK (AMP-activated protein kinase):MOTS-c inomutsa AMPK, yepakati simba sensor, inosimudziraglucose kutora, mafuta acid oxidation, uye mitochondrial biogenesis.
Kuwedzera insulin senitivity:MOTS-c inowedzera insulin kupindura mumhasuru uye adipose tishu, inovandudzaglucose homeostasis.
Kudzivirirwa kweoxidative kusagadzikana uye kuzvimba:Nekugadzirisa cellular redox chiyero uye nzira dzekuzvimba dzinoratidza nzira.
Mutemo we mitochondrial basa uye biogenesis:Inotsigira hutano hwemitochondrial, kunyanya pasi pekunetseka kana kukwegura mamiriro.

Therapeutic Research uye Biological Effects

Zvidzidzo zvepreclinical zvakaratidza huwandu hwakawanda hwehupenyu uye kurapa kweMOTS-c mune zvese zviri zviviri in vitro uye mhuka mhando:

1. Metabolic Disorders (Kufutisa, Type 2 Diabetes, Insulin Resistance)

Inovandudza kushivirira kweglucose uye inoderedza mazinga eglucose eropa
Inosimudzirainsulin sensitivitypasina kuwedzera insulin mazinga
Anosimudzirakuderedza uremu uye mafuta oxidationmumakonzo akafutisa anokonzeresa kudya

2. Anti-Kuchembera uye Kurarama Hurefu

MOTS-c mazinga anoderera nezera, uye kuwedzera mumakonzo akura kwakaratidzwakuwedzera simba remuviri, kuwedzera basa remitochondrial,uyekunonoka kuderera kwezera.
Inovandudza kurovedza muviri uyekutsungirira kwemisumbukuburikidza nekuwedzerwa oxidative metabolism.

3. Mitochondrial uye Cellular Stress Dziviriro

Inosimudziracellular kupona pasi pe metabolic kana oxidative kusagadzikanamamiriro.
Inowedzera kutaura kwemajini anoenderana nekugadzirisa masero uye autophagy.

4. Cardiovascular uye Neuroprotective Potential

Zvidzidzo zvekutanga zvinoratidza MOTS-c inogona kudziviriravascular endothelial maserouye kuderedza cardiac stress markers.
Inogona neuroprotective properties kuburikidzaanti-inflammatory uye antioxidative nziradziri kuongororwa.

API Manufacturing uye Quality Attributes

At Gentolex Group, zveduPurogiramu inonzi MOTS-cinogadzirwa uchishandisasolid-phase peptide synthesis (SPPS)pasi pemamiriro akasimba eGMP-senge, kuve nechokwadi chemhando yepamusoro, kuchena, uye kugadzikana kwekutsvaga uye kushandiswa kwekurapa.