1. Tsanangudzo yeGLP-1
Glucagon-Senge Peptide-1 (GLP-1) ihomoni inowanzoitika inogadzirwa mumatumbo mushure mekudya. Inobata basa rakakosha muglucose metabolism nekukurudzira secretion ye insulin, inhibiting glucagon kuburitswa, kunonoka kubuda mudumbu, uye kukurudzira kunzwa kwekuzara. Izvi zvakasanganiswa zvinokonzeresa kudzora mazinga eshuga yeropa uye zvinobatsira mukuremerwa. Synthetic GLP-1 receptor agonists vanotevedzera aya maitiro echisikigo, achivaita akakosha mukurapa kwerudzi rwechipiri chirwere cheshuga uye kufutisa.
2. Kurongwa neBasa
Zvichienderana nemabasa ayo emuviri, GLP-1 nemaanalogi ayo anogona kukamurwa kuita akati wandei anoshanda mapoka:
- Ropa glucose regulation: Inosimudzira insulin kuburitswa mukupindura kune yakakwira glucose mazinga uku ichidzvanya glucagon secretion.
- Appetite control: Inoita panzvimbo yehuropi yekuda kudya kuderedza kudya uye kuwedzera kuguta.
- Gastrointestinal regulation: Inononoka kubuda mudumbu, kuwedzera kugaya uye kubatsira kudzora postprandial glucose spikes.
- Cardiovascular benefits: Mamwe maGLP-1 receptor agonist akaratidzwa kuderedza njodzi yezviitiko zvikuru zvemoyo muvarwere vane chirwere cheshuga.
- Kudzora uremu: Nekudzora kudya uye nekusimudzira kuderedzwa kwekoriori, GLP-1 analogis anotsigira zvishoma nezvishoma uye kwakaramba kuderera uremu.
3. Hunhu hweGLP-1
GLP-1 ine hafu yehupenyu hupfupi kwazvo-maminetsi mashoma-nekuti inokurumidza kuderedzwa neiyo enzyme DPP-4 (dipeptidyl peptidase-4). Kuti vakunde izvi, vaongorori vemishonga vakagadzira-refu-acting synthetic GLP-1 receptor agonists senge.Semaglutide, Liraglutide, Tirzepatide,uyeRetatrutide.
Aya makomisheni akagadziridzwa anowedzera chiitiko kubva kumaawa kusvika kumazuva kana kunyange mavhiki, achibvumira kamwe-zuva kana kamwe-vhiki dosing.
Hunhu hwakakosha hunosanganisira:
- Glucose-inotsamira chiito: Inoderedza njodzi yehypoglycemia kana ichienzaniswa neyechinyakare insulin kurapwa.
- Nzira mbiri kana katatu (mumishonga mitsva): Dzimwe shanduro dzepamusoro dzinotarisa mamwe mareceptor akadai seGIP kana glucagon receptors, kuwedzera mabhenefiti emagetsi.
- Yakakwana metabolic kunatsiridza: Inodzikisa HbA1c, inovandudza lipid profiles, uye inotsigira uremu.
GLP-1 nemaanalogi ayo akashandura kurapa kwemazuva ano kwemetabolism nekugadzirisa zvese zveshuga uye kufutisa panguva imwe chete-zvichipa kwete chete kudzora shuga yeropa asiwo kwenguva refu yemoyo uye huremu mabhenefiti.
4.GLP-1 Kurapa Solutions
5. Injectable GLP-1 Receptor Agonists
Iyo inonyanya kufarirwa fomu, idzi dzinosanganisira Liraglutide, Semaglutide, uye Tirzepatide. Iyo inopihwa pasi pecutaneously, zuva nezuva kana vhiki nevhiki, ichipa inoenderera receptor activation yekugadzikana kweglucose kutonga uye kudzvinyirirwa kwechido.
5. Oral GLP-1 Receptor Agonists
Sarudzo nyowani, yakadai seOral Semaglutide, inopa varwere-isina nyore nyore. Inoshandisa absorption-enhancing tekinoroji kuchengetedza bioavailability kana yatorwa nemuromo, kuvandudza kutevedzera kurapwa.
6. Combination Therapies (GLP-1 + Dzimwe Nzira)
Mishonga ichiri kusimukira inosanganisa GLP-1 neGIP kana glucagon receptor agonism kuti iwane kuderera kwakasimba kwehuremu uye metabolic zvabuda. Semuenzaniso, Tirzepatide (a dual GIP/GLP-1 agonist) uye Retatrutide (katatu GIP/GLP-1/glucagon agonist) inomiririra chizvarwa chinotevera che metabolic marapirwo.
GLP-1 kurapwa kunoratidza danho rekuchinja mukugadzirisa zvirwere zvisingaperi zvemetabolism-inopa nzira yakabatanidzwa yekudzora shuga yeropa, kuderedza uremu, nekuvandudza hutano hwese.
Nguva yekutumira: Nov-03-2025