SeGLP-1 agonist, inoteedzera maitiro emuviri ega akaburitswa GLP-1 mumuviri.
Mukupindura kudyiwa kweglucose, PPG neurons mukati mepakati tsinga system (CNS) uye L-masero ari mudumbu anogadzira uye anoburitsa GLP-1, inhibitory gastrointestinal hormone.
Mushure mekuburitswa, GLP-1 inomisikidza GLP-1R receptors pane pancreatic β-masero, zvichikonzera nhevedzano yekuchinja kwemetabolism inoratidzwa ne insulin secretion uye kudzvinyirirwa kwechido.
Insulin secretion inotungamira kukudzikira kwese kwemazinga eglucose muropa, kuderera kwekugadzirwa kweglucagon, uye kudzivirira kuburitswa kweglucose kubva muzvitoro zveglycogen zvechiropa. Izvi zvinokonzera satiety, inovandudza insulin senitivity, uye pakupedzisira inoguma mukurasikirwa.
Mushonga unomutsa insulin secretion nenzira inotsamira shuga, nekudaro ichidzikisa njodzi ye hypoglycemia. Mukuwedzera, ine mhedzisiro yakanaka yenguva refu pakupona, kupararira, uye kuvandudzwa kwe-β-masero.
Tsvagiridzo inoratidza kuti semaglutide inonyanya kutevedzera mhedzisiro yeGLP-1 yakaburitswa mudumbu kwete kubva muuropi. Izvi zvinodaro nekuti mazhinji eGLP-1 receptors muhuropi akarara kunze kweiyo inoshanda yeiyi mishonga inopihwa systemic. Pasinei nekuita kwayo kushoma kwakananga pahuropi GLP-1 receptors, semaglutide inoramba ichishanda zvakanyanya mukuderedza kudya uye uremu hwemuviri.
Zvinoita sezvingaite izvi nekumisikidza neuronal network mukati mepakati tsinga sisitimu, mazhinji ayo ari echipiri tarisiro isingaratidzi zvakananga GLP-1 receptors.
Muna 2024, shanduro dzakabvumidzwa dzekutengesa semaglutide dzinosanganisiraOzempic, Rybelsus,uyeWegovymajekiseni, ese akagadzirwa neNovo Nordisk.
Nguva yekutumira: Aug-18-2025