Mumakore achangopfuura, GLP-1 receptor agonists vakakurumidza kuwedzera kubva pakurapa chirwere cheshuga kusvika kune maturusi ekutonga uremu, ikava imwe yenzvimbo dzakatariswa zvakanyanya mumishonga yepasi rose. Kubva pakati pa2025, uku kusimba kunoratidza hapana chiratidzo chekunonoka. Hofori dzeindasitiri Eli Lilly naNovo Nordisk vari mumakwikwi akanyanya, makambani eChinese emishonga ari kuwedzera pasi rose, uye zvinangwa zvitsva uye zviratidzo zviri kuramba zvichibuda. GLP-1 haichisiri chikamu chezvinodhaka - iri kushanduka kuita chikuva chakakwana chekugadzirisa chirwere chemetabolism.
Eli Lilly's tirzepatide yakaunza mhedzisiro inokatyamadza muyedzo yakakura yemoyo yekiriniki yekiriniki, ichiratidza kwete chete kusimba kwakasimba mushuga yeropa uye kuderedza uremu, asiwo kuchengetedzwa kwepamusoro kwemoyo. Vazhinji vanocherekedza maindasitiri vanoona izvi sekutanga kwe "yechipiri kukura curve" yeGLP-1 marapirwo. Zvichakadaro, Novo Nordisk yakatarisana nemhepo-inononoka kutengesa, mihoro inodzikira, uye shanduko yehutungamiriri. Makwikwi ari munzvimbo yeGLP-1 achinja kubva ku "blockbuster battles" kuenda kune yakazara-ecosystem mujaho.
Kupfuura majekiseni, pombi iri kusiyanisa. Oral formulations, mamorekuru madiki, uye masanganiswa ekurapa ari pasi pekuvandudzwa neakasiyana makambani emakambani, ese aine chinangwa chekuvandudza kutevedza kwevarwere uye kumira pachena mumusika wakazara vanhu. Panguva imwe cheteyo, mafemu emishonga ekuChina ari kuita kuti kuvepo kwawo chinyararire, achiwana marezinesi epasi rose anokosha mabhiriyoni emadhora—chiratidzo chesimba riri kuwedzera reChina mukugadzira mishonga.
Zvinotonyanya kukosha, mishonga yeGLP-1 iri kufamba kupfuura kufutisa uye chirwere cheshuga. Zvirwere zvemoyo, chiropa chisiri chinwiwa chinodhaka (NAFLD), chirwere cheAlzheimer, kupindwa muropa, uye kusagadzikana kwekurara zvave kuferefetwa, paine humbowo hunowedzera hunoratidza kugona kweGLP-1 yekurapa munzvimbo idzi. Nepo mazhinji eaya maapplication achiri mukutanga kiriniki matanho, ari kukwezva yakakosha kutsvagisa mari uye kufarira mari.
Nekudaro, kuwedzera kukurumbira kweGLP-1 marapirwo kunounzawo kunetseka kwekuchengetedza. Mishumo ichangoburwa inobatanidza kushandiswa kwenguva refu kweGLP-1 kumatambudziko emazino uye zvisingawanzoitiki optic nerve mamiriro akasimudza mireza mitsvuku pakati peveruzhinji nevanodzora. Kuenzanisa kushanda nekuchengetedzeka kuchave kwakakosha pakukura kweindasitiri.
Zvese zvinhu zvinotariswa, GLP-1 haichisiri nzira yekurapa - yave nhandare yepakati munhangemutange kutsanangura ramangwana rehutano hwemetabolism. Kubva pakuvandudza kwesainzi kusvika pakukanganiswa kwemusika, kubva kumafomu matsva ekutumira kusvika kune yakakura mashandisirwo echirwere, GLP-1 hausi mushonga chete, mukana wekuzvarwa.
Nguva yekutumira: Aug-01-2025