Mumakore achangopfuura, GLP-1 receptor agonists (GLP-1 RAs) yakabuda semutambi akakosha mukurapa chirwere cheshuga uye kufutisa, ikava chikamu chakakosha chekugadzirisa chirwere chemetabolism. Mishonga iyi haingoite basa rakakosha mukudzora shuga yeropa asiwo inoratidza mhedzisiro inoshamisa mukuremerwa uye kudzivirira kwemoyo. Nekuenderera mberi nekufambira mberi mukutsvagisa, hutano hwakanaka hwemishonga yeGLP-1 huri kuwedzera kuzivikanwa nekuyemurwa.
GLP-1 inowanzoitika incretin hormone inovanzwa nematumbu mushure mekudya. Inosimudzira kugadzirwa kwe insulin, inodzvanya kuburitswa kweglucagon, uye inononoka kubuda mudumbu, izvo zvese zvinobatsira pakugadzirisa zvirinani shuga yeropa. GLP-1 receptor agonists, semaglutide, liraglutide, uye tirzepatide, inogadzirwa zvichienderana nemaitiro aya uye inopa maitiro ekurapa anoshanda kune varwere vane Type 2 chirwere cheshuga.
Kupfuura glycemic control, GLP-1 mishonga yakaratidza yakasarudzika kugona mukuderedza uremu. Nekuita pane yepakati tsinga system, ivo vanoderedza kudya uye kuwedzera satiety, zvichikonzera kuderera kwechisikigo mukudya kwecalorie. Zvidzidzo zvekiriniki zvakaratidza kuti varwere vanoshandisa GLP-1 zvinodhaka vanoona kurasikirwa kwakakosha kunyangwe munguva pfupi, uye kushandiswa kwenguva refu kunogona kukonzera kudzikiswa kwe10% kusvika 20% muhuremu hwemuviri. Izvi hazvingogadzirise hupenyu hwese chete asiwo zvinodzikisa njodzi yekufutisa-inoenderana nemamiriro akadai sehypertension, hyperlipidemia, uye isiri-doro fatty chiropa chirwere.
Zvinotonyanya kukosha, mamwe mishonga yeGLP-1 yakaratidza kuvimbisa moyo nemoyo. Tsvagiridzo inoratidza kuti GLP-1 receptor agonists inogona kuderedza njodzi yezviitiko zvakakura zvemoyo, kusanganisira kurohwa kwemoyo uye sitiroko, zvichipa imwe dziviriro kune varwere vane chirwere chemoyo chiripo kana avo vari panjodzi huru. Zvakare, zvidzidzo zvekutanga zviri kuongorora zvavanogona kuita mukusagadzikana kwetsinga senge Alzheimer's uye Parkinson's chirwere, kunyangwe humwe humbowo hunodiwa munzvimbo idzi.
Ehe, mishonga yeGLP-1 inogona kuuya nemimwe mhedzisiro. Zvinonyanyozivikanwa ndezvekusagadzikana kwedumbu sekusvotwa, kurutsa, uye manyoka, kunyanya pakutanga kwekurapa. Zvisinei, zviratidzo izvi zvinowanzopera nekufamba kwenguva. Kana ichishandiswa pasi pekutungamirwa kwehunyanzvi hwekurapa, GLP-1 mishonga inowanzoonekwa yakachengeteka uye inotenderwa zvakanaka.
Mukupedzisa, GLP-1 receptor agonists yakashanduka kubva mukurapa chirwere cheshuga kuita maturusi ane simba ekugadzirisa metabolic. Ivo havangobatsire varwere zvirinani kudzora shuga yavo yeropa asiwo vanopa tariro nyowani yekugadzirisa kufutisa uye kuchengetedza hutano hwemoyo. Sezvo tsvagiridzo ichienderera mberi, mishonga yeGLP-1 inotarisirwa kuita basa rakakura mune ramangwana rehutano.
Nguva yekutumira: Jul-11-2025