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Zita rizere:Muviri Kudzivirira Compound-157, apentadecapeptide (15-amino acid peptide)pakutanga yakaparadzaniswa negastric juice yemunhu.
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Amino acid kutevedzana:Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, molecular uremu ≈ 1419.55 Da.
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Kuenzaniswa nemamwe mapeptide akawanda, BPC-157 haina kugadzikana mumvura uye muto wemudumbu, izvo zvinoita kuti muromo kana gastric kutungamira kuve nyore.
Maitiro Ekuita
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Angiogenesis / Circulatory Recovery
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UpregulatesVEGFR-2kutaura, kukurudzira kuumbwa kwetsinga itsva yeropa.
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Activates theSrc-Caveolin-1-eNOS nzira, inotungamirira ku nitric oxide (NO) kusunungurwa, vasodilation, uye kuvandudzwa kwevascular function.
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Anti-inflammatory uye Antioxidant
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Inodzikamisa pro-inflammatory cytokines sengeIL-6uyeTNF-α.
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Inoderedza reactive oxygen marudzi (ROS) kugadzirwa, kudzivirira masero kubva kune oxidative kusagadzikana.
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Kugadziriswa kweTissue
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Inosimudzira kurongeka uye kushanda kupora mune tendon, ligament, uye tsandanyama kukuvara modhi.
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Inopa neuroprotection mukati mepakati tsinga system kukuvara mhando (spinal cord compression, cerebral ischemia-reperfusion), inoderedza kufa neuronal nekuvandudza mota/sensory kupora.
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Kudzora kweVascular Tone
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Ex vivo vascular zvidzidzo zvinoratidza BPC-157 induces vasorelaxation, zvinoenderana neiyo intact endothelium uye NO nzira.
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Mhuka & In Vitro Kuenzanisa Data
| Test Type | Muenzaniso / Kupindira | Dose / Administration | Kudzora | Key Migumisiro | Kuenzanisa Data |
|---|---|---|---|---|---|
| Vasodilation (rat aorta, ex vivo) | Phenylephrine-precontracted aortic zvindori | BPC-157 kusvika100 μg/ml | Hapana BPC-157 | Vasorelaxation ~37.6 ± 5.7% | Yakaderedzwa kusvika10.0 ± 5.1% / 12.3 ± 2.3%neNOS inhibitor (L-NAME) kana NO scavenger (Hb) |
| Endothelial cell assay (HUVEC) | HUVEC tsika | 1 μg/ml | Kudzora kusina kurapwa | ↑ HAPANA kugadzira (1.35-peta); ↑ kutama kwesero | Kutama kwakabviswa neHb |
| Ischemic lemb model (gonzo) | Hindlimb ischemia | 10 μg/kg/zuva (ip) | Hapana kurapwa | Kukurumidza kuyerera kweropa, ↑ angiogenesis | Kurapa > Kudzora |
| Spinal cord compression (gonzo) | Sacrococcygeal spinal cord compression | Single ip injection 10 min post-kukuvara | Boka risina kurapwa | Kukosha kwetsinga uye kupora kwemaitiro | Boka rekudzora rakaramba rakaremara |
| Hepatotoxicity modhi (CCl₄ / doro) | Kemikari inokonzerwa nekukuvara kwechiropa | 1 µg kana 10 ng/kg (ip / oral) | Kusarapwa | ↓ AST/ALT, yakaderedzwa necrosis | Boka rekudzora rakaratidza kukuvara kwakanyanya kwechiropa |
| Muchetura zvidzidzo | Mbeva, tsuro, imbwa | Multiple doses / nzira | Placebo controls | Hapana yakakosha chepfu, hapana LD₅₀ yakaonekwa | Zvakanaka kushivirirwa kunyange pamadosi akakwirira |
Zvidzidzo zvevanhu
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Case series: Intra-articular injection yeBPC-157 muvarwere ve12 vane marwadzo emabvi → 11 yakashuma kusununguka kukuru kwemarwadzo. Zvisingakwanisi: hapana boka rekutonga, hapana kupofumadza, mhedzisiro.
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Muedzo wekiriniki: A Phase I kuchengeteka uye pharmacokinetic kudzidza (NCT02637284) mu 42 vane hutano vanozvipira yakaitwa, asi migumisiro haina kubudiswa.
Parizvino,hapana yepamusoro-mhando randomized controlled trials (RCTs)dziripo kuti dzisimbise kushanda kwekiriniki uye kuchengeteka.
Kuchengetedzwa & Nengozi Ingangoitika
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Angiogenesis: Inobatsira pakurapa, asi inogona kusimudzira bundu vascularization, kukurumidza kukura kana metastasis muvarwere vekenza.
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Dose & Administration: Inoshanda mumhuka pazviyero zvakaderera zvikuru (ng–µg/kg), asi dhigirii yakakwana yevanhu uye nzira zvinoramba zvisina kutsanangurwa.
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Kushandiswa kwenguva refu: Hapana yakazara-yenguva yakareba chepfu data; zvidzidzo zvizhinji ndezvenguva pfupi.
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Regulatory status: Haina kubvumidzwa semushonga munyika zhinji; yakarongedzwa seachinhu chinorambidzwaneWADA (World Anti-Doping Agency).
Kuenzanisa Maonero & Miganhu
| Kuenzanisa | Simba | Kuganhurirwa |
|---|---|---|
| Mhuka vs Munhu | Inopindirana inobatsira mumhuka (tendon, nerve, kugadzirisa chiropa, angiogenesis) | Uchapupu hwevanhu hushoma, hahudzoreki, uye hunoshaya kutevedza kwenguva refu |
| Dose range | Inoshanda pazviyero zvakaderera mumhuka (ng–µg/kg; µg/ml in vitro) | Yakachengeteka/inoshanda dosing yemunhu isingazivikanwe |
| Kutanga kwechiito | Early post-injury administration (semuenzaniso, 10 min mushure mekukuvara kwemusana) inobereka kupora kwakasimba | Kugoneka kwekiriniki yenguva yakadaro hakuna kujeka |
| Muchetura | Hapana dhigirii inouraya kana mhedzisiro yakaipa inocherechedzwa mumhando dzemhuka dzakawanda | Yenguva refu chepfu, carcinogenicity, uye kuchengetedzwa kwekubereka zvinoramba zvisina kuongororwa |
Mhedziso
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BPC-157 inoratidza yakasimba regenerative uye inodzivirira mhedzisiro mumhuka uye masero modhi: angiogenesis, anti-inflammation, kugadziriswa kwetishu, neuroprotection, uye hepatoprotection.
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Umbowo hwevanhu hwakaganhurirwa zvikuru, isina data yakasimba yekiriniki yekuedza iripo.
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Uyezveyakanyatsogadzirirwa randomized controlled trialszvinodikanwa kumisikidza kushanda, chengetedzo, yakakwana dosing, uye nzira dzekutonga muvanhu.
Nguva yekutumira: Sep-23-2025