Mounjaro(Tirzepatide) mushonga wekuderedza uremu uye kugadzirisa une chinhu chinoshanda tirzepatide. Tirzepatide inogara ichiita mbiri mbiri GIP uye GLP-1 receptor agonist. Zvose zvinogamuchirwa zvinowanikwa mupancreatic alpha uye beta endocrine masero, mwoyo, tsinga dzeropa, immune masero (leukocytes), matumbo uye itsvo. GIP receptors inowanikwawo mune adipocytes.
Uye zvakare, ese ari maviri GIP uye GLP-1 receptors anoratidzwa muhuropi matunhu akakosha pakuda kudya. Tirzepatide inonyanya kusarudzira vanhu GIP uye GLP-1 receptors. Tirzepatide ine hukama hwepamusoro kune ese GIP uye GLP-1 receptors. Chiitiko chetirzepatide paGIP receptors chakafanana neicho cheyakasikwa GIP hormone. Chiitiko chetirzepatide paGLP-1 receptors chakaderera pane icho cheyakasikwa GLP-1 hormone.
Mounjaro (Tirzepatide) inoshanda nekuita pane zvinogamuchirwa muuropi zvinodzora havi, zvichiita kuti unzwe wakaguta, usina nzara, uye kashoma kuda chikafu. Izvi zvichakubatsira kudya zvishoma uye kuderedza uremu.
Mounjaro inofanirwa kushandiswa neyakaderedzwa-calorie yekudya chirongwa uye yakawedzera kuita kwemuviri.
Inclusion Criteria
Mounjaro (Tirzepatide) inoratidzwa pakugadzirisa uremu, kusanganisira kuderedza uremu uye kuchengetedza, sechibatanidzwa kune yakaderedzwa-calorie kudya uye kuwedzera kwekuita muviri muvakuru vane yekutanga body mass index (BMI) ye:
≥ 30 kg/m2 (yakafuta), kana
≥ 27 kg/m2 kusvika <30 kg/m2 (yakawandisa) ine kanenge kamwe-kamwe kanoenderana nehuremu hwakadai sedysglycemia (prediabetes kana Type 2 chirwere cheshuga), hypertension, dyslipidemia, kana kuvharidzira kutadza kurara
Age 18-75 makore
Kana murwere akatadza kurasikirwa ne5% yehuremu hwavo hwekutanga mushure memwedzi mitanhatu yekurapwa, sarudzo inoda kuitwa kuti ienderere mberi nekurapa, tichifunga nezvekubatsira / njodzi yemurwere wega.
Dosing purogiramu
Nhamba yekutanga yetirzepatide ndeye 2.5 mg kamwe chete pavhiki. Mushure memavhiki e4, chirwere chinofanira kuwedzerwa kusvika ku 5 mg kamwe chete pavhiki. Kana zvichidiwa, muyero unogona kuwedzerwa ne 2.5 mg kwemavhiki mashoma e4 pamusoro peyero yezvino.
Iyo yakakurudzirwa kuchengetedza doses ndeye 5, 10, uye 15 mg.
Iyo yakanyanya dose ndeye 15 mg kamwe pavhiki.
Dosing nzira
Mounjaro(Tirzepatide) inogona kupihwa kamwe pasvondo chero nguva yezuva, ine kana isina chikafu.
Inofanirwa kubaiwa pasi peguvhu mudumbu, chidya, kana kumusoro ruoko. Nzvimbo yejekiseni inogona kuchinjwa. Haifanirwe kubaiwa intravenously kana intramuscularly.
Kana zvichidikanwa, zuva revhiki nevhiki dosing rinogona kuchinjwa chero nguva iri pakati pemadhodhi ingangoita mazuva matatu (> 72 maawa). Kana zuva idzva redosing rasarudzwa, dosing inofanira kuenderera kamwe pavhiki.
Varwere vanofanirwa kurairwa kuti vaverenge mirairo yekushandiswa mupasuru isa nekungwarira vasati vatora mushonga.
Nguva yekutumira: Feb-15-2025