Orlistat 96829-58-2 Kuderedza Kunyura kweSietary Fat, Zvinokonzera Kurasikirwa Kwehuremu
Product Detail
| Zita | Orlistat |
| CAS nhamba | 96829-58-2 |
| Molecular formula | C29H53NO5 |
| Molecular uremu | 495.73 |
| Nhamba yeEINECS | 639-755-1 |
| Melting Point | <50°C |
| Density | 0.976±0.06g/cm3(Zvakafanotaurwa) |
| Kuchengetedza mamiriro | 2-8°C |
| Form | Upfu |
| Color | Chena |
| Acidity coefficient | (pKa) 14.59±0.23 (Zvakafanotaurwa) |
Mashoko anoreva zvakafanana
(S)-2-FORMYLAMINO-4-METHYL-PENTANOICACID(S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]-DODECYLESTER;RO-18-0647;(-)-TETRAHYDROLIPSTAN; ORMYL-L-LEUCINE(1S)-1-[[(2S,3S)-3-HEXYL-4-OXO-2-OXETANYL]METHYL]DODECYLESTER;Orlistat(synthetase/compound);Orlistat(synthesis);Orlistat(FerMentation)
Pharmacological Effect
Properties
White crystalline poda, inenge isinganyungudike mumvura, inonyungudika zviri nyore muchloroform, yakanyanya kunyungudika mumethanol uye ethanol, iri nyore kuita pyrolyze, nzvimbo yekunyungudika i40 ℃～42 ℃. Morekuru yaro diastereomer ine ina chiral centers, pane wavelength ye529nm, mhinduro yayo ethanol ine negative optical rotation.
Mode of Action
Orlistat inogara kwenguva refu uye ine simba chaiyo gastrointestinal lipase inhibitor, iyo inactivates ma enzymes maviri ari pamusoro apa nekugadzira covalent bond pamwe nekushanda serine site ye lipase mudumbu uye mudumbu muduku. Inactivated enzymes haigoni kuputsa mafuta muzvokudya mumafuta asina mafuta acids uye Chemicalbook glycerol inogona kutorwa nemuviri, nokudaro kuderedza kudyiwa kwemafuta uye kuderedza uremu. Mukuwedzera, zvimwe zvidzidzo zvakawana kuti orlistat inhibits intestinal absorption yecholesterol nekudzivisa niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).
Zviratidzo
Ichi chigadzirwa pamwe chete nehunyoro hwe hypocaloric chikafu chinoratidzwa kune kurapwa kwenguva refu kwevanhu vakafuta uye vakafutisa, kusanganisira avo vane njodzi dzakasimbiswa dzine chekuita nekufutisa. Ichi chigadzirwa chine uremu hwenguva refu (kurasikirwa uremu, kuchengetedza uremu uye kudzivirira rebound) kushanda. Kutora orlistat kunogona kuderedza kufutisa-kwakabatana nenjodzi zvinhu uye chiitiko chezvimwe zvirwere zvine chekuita nekufutisa, zvinosanganisira hypercholesterolemia, Type 2 chirwere cheshuga, kusagadzikana kweglucose kushivirira, hyperinsulinemia, hypertension, uye nhengo yekuderedza mafuta zvirimo.
Kudyidzana Kwemishonga
Inogona kuderedza kubatwa kwevhitamini A, D uye E. Inogona kuwedzerwa nechigadzirwa ichi panguva imwe chete. Kana uri kutora gadziriro dzine mavitamini A, D uye E (zvakadai semamwe multivitamini), unofanira kutora chigadzirwa ichi maawa maviri mushure mekutora chigadzirwa ichi kana pakuvata. Vanhu vane chirwere cheshuga cherudzi rwechipiri vangada kuderedza chiyero chemuromo hypoglycemic agents (semuenzaniso, sulfonylureas). Co-administration ne cyclosporine inogona kukonzera kuderera kwehuwandu hweplasma hwekupedzisira. Kushandisa pamwe chete amiodarone kunogona kukonzera kuderera kwekutora kwekupedzisira uye kuderedza kushanda.
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