OrClistat 96829-58-2 Kuderedza Kunyudza Kwemafuta Mafuta, Kunokonzerwa Mukurema Kwemaremu
Chigadzirwa Chinhu
| Zita | Orlistat |
| Nhamba | 96829-58-2 |
| Molecular Formula | C29H53no5 |
| Sreek inoremerwa | 495.73 |
| Einecs nhamba | 639-755-1 |
| Inonyungudika | <50 ° C |
| Density | 0.976 ± 0.06g / cm3 (yakafanotaurwa) |
| Kuchengetedza mamiriro | 2-8 ° C |
| Fomu | Poda |
| Ruvara | Chena |
| Acidity coefficient | (pka) 14.59 ± 0.23 (akafanotaura) |
Synonyms
(S) -2-fomuylomino-4-methyl-pentanoicicocid (s) -1 - [ Ormyl-L-Lucine (1s) -1 - [[(2-Oxyll-4-OxNET (Synthetas); Ornthesis (Synthesis); Ornthesis
Pharmacological mhedzisiro
Zvivakwa
White Crystalline poda, anenge asinganzwisisike mumvura, anonyura muChloroform, anonyura mukati me methanol uye ethanol, zviri nyore kuPyronde, inonyungudika ndeye 40 ℃ ~ 42 ℃. Molekyuli yayo inonzi dhairteree ine machirisa ina yechipera, pane wavelength of 529nm, itshanol mhinduro ine yakaipa nzvimbo yekutenderera.
Maitiro ekuita
Orlistat ndeye refu-inobata uye ine simba gastrointestinal lipbitor, iyo inoshandisa iyo yepamusoro enzymes nekuumba chisungo chevanobatanidza neyechivande site site yedumbu uye mudumbu madiki. Itsacivated enzymes haigoni kuputsa mafuta mune zvekudya mumahara emakiromita eAcids uye kemalbook glycerol inogona kuyamwa nemuviri, nekudaro kudzikisa mafuta kudya uye kuderedza uremu. Uyezve, zvimwe zvidzidzo zvakawana kuti Orlistat inhibits intestinal yekunyudza ye cholesterol neye Biresn-st protein 1 (Niemann-pictc1-like1, npc1l1).
Zviratidzo
Ichi chigadzirwa musanganiswa neyekudya zvinyoro zvekudya zvinoratidza kuti kurapwa kwenguva refu kwevanhu vane simba uye vakanyanya kuremerwa, kusanganisira izvo zvine njodzi dzakaomeswa dzakabatana nekufutisa. Ichi chigadzirwa chine refu-terrect uremu kutonga (uremu kurasikirwa, kurema uremu uye kudzivirira kwekudzoreredza) kushanda. Kutora Orlistat kunogona kuderedza zvinhu zvine njodzi zvine chekuita nezvimwe zvinhu zvine chekuita nehoshayiridzo, kusanganisira chirwere cheshuga.
Kurongeka kwekudyidzana
Inogona kuderedza kusimuka kweVitamini A, D uye E. Inogona kuwedzerwa nechigadzirwa ichi panguva imwe chete. Kana iwe uri kutora gadziriro ine mavitamini a, d uye e (sekuti mamwe midzi yakawanda), iwe unofanirwa kutora ichi chigadzirwa maawa maviri mushure mekutora ichi chigadzirwa kana panguva yekurara. Vanhu vane mhando 2 chirwere cheshuga chingangoda kuderedza dosi renzvimbo yemuromo hypoglycemeem (semuenzaniso, sulfonylureas). Co-manejimendi neCyclosporine inogona kukonzera kuderera kwemasikati ekuvanzika kwepashure. KUSHANDISA KUSHANDISA kweAmiodrorone kunogona kuguma nekudzoreredzwa kwekutanga kwekupedzisira uye kuderedzwa kushanda.
