Pharma Ingredients
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Inclisiran sodium
Inclisiran sodium API (Active Pharmaceutical Ingredient) inodzidzwa kunyanya mumunda weRNA kupindira (RNAi) uye kurapa kwemwoyo. SeSiRNA ine tambo mbiri yakanangana nePCSK9 gene, inoshandiswa mu preclinical uye kiriniki yekutsvagisa kuongorora maitiro-akareba-anoita gene-kunyarara nzira dzekudzikisa LDL-C (yakaderera-density lipoprotein cholesterol). Iyo inoshandawo semuenzaniso wekomboni yekuongorora siRNA yekuendesa masisitimu, kugadzikana, uye chiropa-yakanangwa RNA therapeutics.
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Fmoc-Gly-Gly-OH
Fmoc-Gly-Gly-OH idipeptide inoshandiswa sechinhu chekutanga chekuvaka mune yakasimba-phase peptide synthesis (SPPS). Iyo inoratidzira maviri glycine zvakasara uye Fmoc-yakachengetedzwa N-terminus, inobvumira inodzorwa peptide cheni kureba. Nekuda kwehukuru hudiki hweglycine uye kuchinjika, dipeptide iyi inowanzodzidzwa mukati meiyo peptide backbone dynamics, linker dhizaini, uye chimiro chekumisikidza mumapeptide nemapuroteni.
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Fmoc-Thr(tBu)-Phe-OH
Fmoc-Thr(tBu)-Phe-OH idipeptide building block inowanzoshandiswa mune yakasimba-phase peptide synthesis (SPPS). Fmoc (9-fluorenylmethyloxycarbonyl) boka rinodzivirira N-terminus, nepo tBu (tert-butyl) boka rinodzivirira hydroxyl side chain yethreonine. Iyi dipeptide yakadzivirirwa inodzidzwa nezve basa rayo mukufambisa kwakaringana peptide kurebesa, kudzikisira kumhanya, uye kuenzanisira chaiyo inoteedzana modhi muchimiro cheprotein uye zvidzidzo zvekudyidzana.
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AEEA-AEEA
AEEA-AEEA is hydrophilic, inochinjika spacer inowanzoshandiswa mu peptide uye zvinodhaka conjugation research. Inosanganisira maviri ethylene glycol-based units, zvichiita kuti zvive zvakakosha pakudzidza migumisiro ye linker kureba uye kushanduka pakubatana kwema molecular, solubility, uye biological chiitiko. Vatsvagiri vanowanzo shandisa zvikamu zveAEEA kuongorora kuti ma spacers anopesvedzera sei mashandiro eantibody-drug conjugates (ADCs), peptide-drug conjugates, uye mamwe bioconjugates.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide10-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH
Mushonga uyu unodzivirirwa, unoshanda lysine derivative inoshandiswa mu peptide synthesis uye drug conjugate development. Inosanganisira Fmoc boka reN-terminal kudzivirira, uye rutivi-cheni kuchinjwa neEic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), uye AEEA (aminoethoxyethoxyacetate). Izvi zvikamu zvakagadzirirwa kudzidza lipidation mhedzisiro, spacer chemistry, uye inodzorwa kuburitswa kwezvinodhaka. Inotsvakurudzwa zvakanyanya mumamiriro ezvinhu emishonga yeprodrug, ADC linkers, uye membrane-interacting peptides.
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![Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide9-300x300.png)
Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH
Mushonga uyu wakagadziridzwa lysine derivative inoshandiswa mupeptide synthesis, kunyanya pakuvaka anonangwa kana akawanda anoshanda peptide conjugates. Boka reFmoc rinobvumira nhanho synthesis kuburikidza neFmoc solid-phase peptide synthesis (SPPS). Cheni yepadivi yakagadziridzwa ine stearic acid inotorwa (Ste), γ-glutamic acid (γ-Glu), uye maviri AEEA (aminoethoxyethoxyacetate) linkers, ayo anopa hydrophobicity, kuchaja zvivakwa, uye kuchinjika nzvimbo. Inowanzodzidzwa nezvebasa rayo muhurongwa hwekuunza zvinodhaka, kusanganisira antibody-drug conjugates (ADCs) uye cell-inopinda peptides.
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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHtetrapeptide yakachengetedzwa inoshandiswa mu peptide synthesis uye zvidzidzo zvemaitiro. Boka reBoc (tert-butyloxycarbonyl) rinodzivirira N-terminus, nepo Trt (trityl) mapoka anodzivirira cheni dzeparutivi dze histidine uye glutamine kudzivirira kuita kusingadiwe. Kuvapo kweAib (α-aminoisobutyric acid) kunokurudzira kuumbwa kwehelical uye kunowedzera kugadzikana kwepeptide. Iyi peptide yakakosha pakuongorora kupeta peptide, kugadzikana, uye sechikafu chekugadzira biologically active peptides.
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Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH
Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OHtetrapeptide yakachengetedzwa inowanzoshandiswa mukutsvaga peptide synthesis. Mapoka eBoc (tert-butyloxycarbonyl) uye tBu (tert-butyl) anoshanda semapoka anodzivirira kudzivirira maitiro eparutivi panguva yekuungana kwepeptide. Iko kuiswa kweAib (α-aminoisobutyric acid) kunobatsira kusimudzira helical zvimiro uye kuwedzera peptide kugadzikana. Iyi peptide inoteedzana inodzidzwa kugona kwayo mukuongorora kwe conformation, peptide kupeta, uye sechivakwa chekuvaka mukugadzira bioactive peptides ine kusimba kwakasimba uye hunhu.
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Fmoc-Ile-Aib-OH
Fmoc-Ile-Aib-OH chivakwa chedipeptide chinoshandiswa mune yakasimba-phase peptide synthesis (SPPS). Inobatanidza isoleucine yeFmoc-yakachengetedzwa neAib (α-aminoisobutyric acid), isiri-yakasikwa amino acid iyo inowedzera kugadzikana kwehelix uye kudzivirira kweprotease.
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![Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH](https://cdn.globalso.com/gentolexgroup/Glepaglutide6-300x300.png)
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH is functionalized amino acid building block yakagadzirirwa kuendeswa kwezvinodhaka uye bioconjugation. Iyo inoratidzira Eic (eicosanoid) moiety yekusangana kwelipid, γ-Glu yekunongedza, uye AEEA spacers yekuchinjika.
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Boc-Tyr(tBu)-Aib-OH
Boc-Tyr(tBu)-Aib-OH chivakwa chedipeptide chakachengetedzwa chinoshandiswa mukugadzirwa kwepeptide, kusanganisa Boc-protected tyrosine neAib (α-aminoisobutyric acid). Iyo Aib yakasara inosimudzira helix kuumbwa uye protease kuramba.
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Boc-His(Trt)-Ala-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Ala-Glu(OtBu)-Gly-OH inhengo yakachengetedzwa yetetrapeptide inoshandiswa mune yakasimba-phase peptide synthesis (SPPS) uye peptide zvinodhaka kugadzirwa. Inosanganisira mapoka ekudzivirira e orthogonal synthesis uye inoratidza kutevedzana kunobatsira mu bioactive uye dhizaini peptide dhizaini.