Pharma Ingredients
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Fmoc-Ls(Pal-Glu-OtBu)-OH
Fmoc-Ls(Pal-Glu-OtBu) -OH inyanzvi ye lipidated amino acid yekuvaka yakagadzirirwa peptide-lipid conjugation. Iyo inoratidzira Fmoc-yakachengetedzwa lysine ine palmitoyl-glutamate parutivi cheni, inosimudzira membrane kubatana uye bioavailability.
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Fmoc-His-Aib-OH
Fmoc-His-Aib-OH idipeptide building block inoshandiswa mu peptide synthesis, kusanganisa Fmoc-protected histidine ne Aib (α-aminoisobutyric acid). Aib inosvitsa conformational rigidity, ichiita kuti ive yakakosha pakugadzira helical uye yakagadzikana peptides.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH chidimbu chetetrapeptide chakachengetedzwa chinoshandiswa mukugadzirwa kwepeptide uye kukura kwezvinodhaka. Iyo ine zvine hungwaru akadzivirirwa mapoka anoshanda ekuita nhanho yekubatanidza uye inoratidzira Aib (α-aminoisobutyric acid) yekusimudzira helix kugadzikana uye conformational kusimba.
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU inogadzira lipidated linker molecule yakagadzirirwa kuendeswa kwezvinodhaka uye antibody-drug conjugates (ADCs). Iyo inoratidzira stearoyl (Ste) hydrophobic muswe, γ-glutamyl inonangisa motif, AEEA spacers yekuchinjika, uye OSu (NHS ester) boka rekubatana kwakanaka.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH inogadzirwa yakachengetedzwa tripeptide chivakwa chekuvaka chine α-methylated leucine, inowanzoshandiswa mu peptide dhizaini dhizaini kuti iwedzere kugadzikana kwemetabolism uye kusarudzwa kwekugamuchira.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) ndeye synthetic zwitterionic detergent inoshandiswa zvakanyanya mu membrane protein research uye structural biology, kunyanya muNMR spectroscopy uye crystallography.
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Donilorsen
Donidalorsen API is an antisense oligonucleotide (ASO) iri pasi pekuferefeta kurapwa kwenhaka angioedema (HAE) uye ine hukama hwekuzvimba mamiriro. Inodzidzwa mumamiriro ezvinhu eRNA-inotarirwa marapirwo, nechinangwa chekudzikisa kutaura kweplasma prekallikrein(KLKB1 mRNA). Vatsvagiri vanoshandisa Donidalorsen kuti vatarise maitiro ekunyararidza majini, dosi-inotsamira pharmacokinetics, uye kudzora kwenguva refu kwebradykinin-mediated kuzvimba.
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Fitusiran
Fitusiran API ndeyekugadzira diki inopindira RNA (siRNA) yakaongororwa zvakanyanya mumunda wehemophilia uye coagulation kusagadzikana. Inonangana neantithrombin (AT kana SEPINC1)gene muchiropa kuderedza kugadzirwa kwe antithrombin. Vatsvakurudzi vanoshandisa Fitusiran kuongorora RNA interference (RNAi) nzira, chiropa-chaiyo gene kunyarara, uye novel nzira dzekurapa dzekugadzirisazve coagulation muhemophilia A uye B varwere, vane kana vasina inhibitors.
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Givosiran
Givosiran API is a synthetic small interfering RNA (siRNA) yakadzidzira kurapwa kweacute hepatic porphyria (AHP). Inonyanya kunanga iyoALAS1gene (aminolevulinic acid synthase 1), iyo inobatanidzwa muheme biosynthesis nzira. Vatsvakurudzi vanoshandisa Givosiran kuongorora RNA interference (RNAi) -based therapies, chiropa-chinonangwa gene kunyarara, uye modulation ye metabolic nzira dzinobatanidzwa mu porphyria uye ane hukama hwemajini kusagadzikana.
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Plozasiran
Plozasiran API is a synthetic diki inopindira RNA (siRNA) yakagadzirirwa kurapwa kwe hypertriglyceridemia uye ine hukama hwemoyo uye metabolic kusagadzikana. Inonangana neAPOC3gene, iyo inokodha apolipoprotein C-III, mutongi akakosha we triglyceride metabolism. Mukutsvagisa, Plozasiran inoshandiswa kudzidza RNAi-based lipid-kudzikisa marongero, gene-kunyarara, uye kwenguva refu-kuita marapirwo emamiriro ezvinhu akadai semhuri chylomicronemia syndrome (FCS) uye yakasanganiswa dyslipidemia.
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Zilebesiran
Zilebesiran API ndeyekuferefeta diki inopindira RNA (siRNA) yakagadzirirwa kurapwa kwehypertension. Inonangana neAGTgene, iro rinoisa angiotensinogen - chikamu chakakosha che renin-angiotensin-aldosterone system (RAAS). Mukutsvaga, Zilebesiran inoshandiswa kudzidza nzira dzekunyarara kwemajini kwenguva refu yekudzivirira kweropa, RNAi kuburitsa matekinoroji, uye basa rakakura reiyo RAAS nzira muzvirwere zvemoyo uye renal.
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Caspofungin yeAntifungal Infections
Zita: Caspofungin
Nhamba yeCAS: 162808-62-0
Molecular formula: C52H88N10O15
Molecular uremu: 1093.31
Nhamba yeEINECS: 1806241-263-5
Poindi yekubikira: 1408.1±65.0 °C (Yakafanotaurwa)
Density: 1.36±0.1 g/cm3(Zvakafanotaurwa)
Acidity coefficient: (pKa) 9.86±0.26 (Yakafanotaurwa)