Plozasiran

Plozasiran (API)

Tsvagiridzo Yekushandisa:
Plozasiran API is a synthetic diki inopindira RNA (siRNA) yakagadzirirwa kurapwa kwe hypertriglyceridemia uye ine hukama hwemoyo uye metabolic kusagadzikana. Inonangana neAPOC3gene, iyo inokodha apolipoprotein C-III, mutongi akakosha we triglyceride metabolism. Mukutsvagisa, Plozasiran inoshandiswa kudzidza RNAi-based lipid-kudzikisa marongero, gene-kunyarara, uye kwenguva refu-kuita marapirwo emamiriro ezvinhu akadai semhuri chylomicronemia syndrome (FCS) uye yakasanganiswa dyslipidemia.

Basa:
Plozasiran inoshanda nekunyararaAPOC3mRNA muchiropa, zvichiita kuti kuderedza apolipoprotein C-III mazinga. Izvi zvinokurudzira kuwedzera lipolysis uye kucheneswa kwe triglyceride-rich lipoprotein kubva muropa. SeA API, Plozasiran inogonesa kugadzirwa kwenguva refu yekurapa inotarisirwa kuderedza zvakanyanya triglyceride mazinga uye kuderedza njodzi yepancreatitis uye zviitiko zvemoyo kune varwere vane zvakanyanya kana genetic lipid kusagadzikana.