Tadalafil 171596-29-5-5 chete kubata erectile styfunction muvarume
Chigadzirwa Chinhu
| Zita | Tadalafil |
| Nhamba | 1715996-29-5 |
| Molecular Formula | C22H19N3O4 |
| Sreek inoremerwa | 389.4 |
| Einecs nhamba | 687-782-2 |
| Kutenderera chaiko | D20 + 71.0 ° |
| Density | 1.51 ± 0.1G / cm3 (yakafanotaurwa) |
| Kuchengetedza mamiriro | 2-8 ° C |
| Fomu | Poda |
| Acidity coefficient | (pka) 16.68 × 0.40 (akafanotaura) |
| Solubility yemvura | DMSO: Soluble 20mg / ml, |
Synonyms
Tadalafil; Cialis; IC IC 351; (6R, 12ar) -6- (Benzo [dfi)-5-methyldropyrazino [1 Tetrahydropyrazino [1 Tetrahydropyrazino [1 ', 2': GF 196960; iCON 351;
Pharmacological mhedzisiro
Tadalalafil (tadalafil, tadalafil) ine molecular formula ye c22h19n3o4 uye inoremerwa uremu hwa 389.4. Izvo zvakange zvashandiswa zvakanyanya mukurapa kweyechirume erectile dysfunction kubvira 2003, nezita rekutengeserana cialis (cialis). Muna June 2009, FDA yakatenderwa tadalafil muUnited States yekurapa kwevarwere nePulmonary Arterial Hypertension (Pah) pasi pezita rekutengeserana Adcirca. Tadalafil yakaunzwa muna 2003 semishonga yekurapa kwaEd. Zvinotora mhedzisiro maminetsi makumi matatu mushure mekutonga, asi zvakanakisa mhedzisiro ndeyekutanga kwekuita, uye mhedzisiro yacho inogona kugara kwe36h, uye mhedzisiro yacho haina kukanganiswa nechikafu. Dook yeTadalafil ndeye 10 kana 20 mg, iyo yekutanga yakakurudzirwa doses ndeye 10 mg, uye iyo dofo inogadziridzwa zvinoenderana nemhinduro yemurwere uye kuita kwakashata. Pre-Market Zvidzidzo zvakaratidza kuti mushure memuromo matanho egumi kana 20 mg yeTadalafil kwemavhiki gumi nemaviri, iyo inoshanda huwandu ndeye 67% uye 81%, zvichiteerana. Zvidzidzo zvakawanda zvakaratidza kuti tadalafil ine zvirinani kushanda zviri nani mukurapwa kweEd.
Erectile dysfunction: Tadalafil ndeye sarudza phosphodieseresery Type Type Type Type Type Type Type Type, asi chimiro chavo chakasiyana neyekupedzisira, uye chikafu chakakura mafuta hachipindire nekunyora kwayo. Pasi pechiitiko chekurudziro yebonde, nitric oxide syntialy (nos) muPentile nerve magumo uye vascular endhelial masero anogadzira syncesis yeNitresh Hapana Anoshanda muPuyanlate Cyclase, ndeipi shandura Guanosesphate to cyclic Guanosphate (CGMP) Phosphodiesererase mhando 5 (PDE5) degrades cgm mune zvisina basa zvigadzirwa, kugadzira penis munzvimbo isina kusimba. Tadalafil inhibits iyo degradation yePde5, inotungamira kuunganidzwa kweCGMP, iyo inozorodza tsandanyama yakatsiga yeCorpus Cavernosum, inotungamira kune iyo penile erection. Sezvo netrate hadzipunze, kushandiswa kwakabatanidzwa ne tadalafil kuchawedzera zvakanyanya huwandu hweCGMP uye kutungamira kune hypension yakanyanya. Naizvozvo, kushandiswa kwakabatana kwevaviri kunosanganiswa mukuita kwekiriniki.
Tadalafil inoshanda nekunyadzisa pdes. GMP inosvibiswa, yakasanganiswa yekushandiswa nemusoro zvine njerates inogona kukonzera kudonha kwakanyanya muropa uye kuwedzera njodzi yekunyepedzera. Cy3pa4 Inducer ichaderedza kusanganisa kweTadanafilil, uye musanganiswa naRifampin, CimTithine, Carthromycin, Kiton, uye Hvi Revhitiko Vanogona Kuwedzera Kuvhiringidza kweropa kunofanirwa kugadziriswa. Parizvino, hapana mishumo yekuti iyo fammacokinetic parameter echinhu ichi chinokanganiswa nekudya uye doro.
