Tianeptine ye5-HT system, sedation, anti-acetylcholine uye cardioxicity yekuora mwoyo
Chigadzirwa Chinhu
| Zita | Tianeptine |
| Nhamba | 1224690-84-9 |
| Molecular Formula | C21H27CLN2O8S2 |
| Sreek inoremerwa | 535.02 |
| Inonyungudika | 129-131 ° C |
| Boiling Point | 609.2îc na760 mmhg |
| Kuchena | 99% |
| Chengetedza | Chisimbiso muakaoma, tembiricha yekupisa |
| Fomu | Poda |
| Ruvara | Chena |
| Kurongedza | Pe bag + aluminium bhegi |
Synonyms
Thm; tianeptinihemisulfatemononohydrate (thm); Tongknghinulfate Powder / Tianeptinsulfate
Pharmacological mhedzisiro
Pharmacological mhedzisiro
1. Iyo anderepressant maitiro echigadzirwa ichi akasiyana neiyo yetsika tca. Inogona kuwedzera iyo inokwira ye5-ht mune synaptic cleft, asi ine simba risinganyariki pane kusashandurazve kwe5-ht na na. Inogona kunge iine mhedzisiro yekuvandudza 5-ht neuronal kutapurirana. Izvo hazvina kushamwaridzana kwema m receptors, H1, α1 na α2-na Receptors.
2. Kubudirira kweAndidepress Iko kushanda kwechigadzirwa ichi kwakafanana neiyo yeSSRI Fluoxetine.
3. Mhuka inodhaka yakaratidza kuti inogona: Wedzera chiitiko chinongoitika chePiramidhi masero mumvuvuu muhuvhu uye nekumhanyisa kudzoreredzwa kwebasa rayo mushure mekunzwa. Wedzera iyo reabsorption ye5-hydroxytryptamine neNeurons mune cerebral cortex neHippocampus.
Kuongorora kwedepe
- Acute, Subachute uye yakareba-refu-testity testity bvunzo: Hapana shanduko mu biology, chiropa basa, pathological anatomy.
- Kubereka Thupfu uye Teratogenicity Test: Tianeptine haina chekuita nekugona kubereka kwevabereki vakabatwa uye pane fetus uye mwana.
- MutageniCity Test: Tianeptine haina mu mumagenic maitiro.
Mhedzisiro
-Kurwadziswa kweEpigastric, kurwadziwa mudumbu, muromo wakaoma, anorexia, kusvotwa, kurutsa, kuputika, kubata kumeso;
- Insomnia, kusimuka, hope, kushaya simba;
- Tachycardia, dentrosstsoles, marwadzo okurwadziwa;
- Kuzeza, musoro, kupera simba, kudzima, kudengenyeka, kuchema kwechiso;
- kupfupika kwekufema, kunzwa kwekusangana muhuro;
- Myalgia, kurwadziwa kumashure, nezvimwe.
