Zilebesiran

Zilebesiran (API)

Tsvagiridzo Yekushandisa:
Zilebesiran API ndeyekuferefeta diki inopindira RNA (siRNA) yakagadzirirwa kurapwa kwehypertension. Inonangana neAGTgene, iro rinoisa angiotensinogen - chikamu chakakosha che renin-angiotensin-aldosterone system (RAAS). Mukutsvaga, Zilebesiran inoshandiswa kudzidza nzira dzekunyarara kwemajini kwenguva refu yekudzivirira kweropa, RNAi kuburitsa matekinoroji, uye basa rakakura reiyo RAAS nzira muzvirwere zvemoyo uye renal.

Basa:
Zilebesiran inoshanda nekunyararaAGTmRNA muchiropa, zvichikonzera kuderedzwa kwekugadzirwa kweangiotensinogen. Izvi zvinotungamirira kukudzikira kwakadzika kweangiotensin II mazinga, zvichibatsira kudzikisa BP nenzira inoenderera. Se API, Zilebesiran inogonesa kugadzirwa kwenguva refu, subcutaneous antihypertensive therapies ine mukana wekota kana biannual dosing, ichipa kunatsiridza kuomerera uye kutonga kweropa.