BPC-157
BPC-157 API
BPC-157 (zita rakazara: Body Protection Compound 157) is a synthetic short peptide inoumbwa ne 15 amino acids, inotorwa kubva mukutevedzana kwemapuroteni anodzivirira echisikigo mujusi redumbu remunhu. Yakaratidza hukuru hwekugadzirisa matishu uye anti-kuzvimba masimba muzvidzidzo zvekuyedza uye inoonekwa zvakanyanya seanovimbisa akawanda anoshanda peptide mushonga.
Sechinhu chinoshanda chemishonga (API), BPC-157 yakashandiswa munzvimbo dzakawanda dzekutsvakurudza kwesayenzi pasi rose kuti iongorore basa rayo rehupenyu mumakumbo emimba, musculoskeletal system, nervous system, cardiovascular system uye kugadziriswa kwetishu dzakapfava, kunyanya mukugadzirisa marwadzo uye anti-inflammatory research.
Tsvagiridzo uye pharmacological nzira yekuita
BPC-157 yakave yakadzidzwa zvakanyanya, kunyanya mu vivo zviedzo zvemhuka uye in vitro cell modhi, uye yakawanikwa iine inotevera musimboti wemishonga mhedzisiro:
1. Kuvandudzwa kwetishu uye kugadzirisa kushungurudza
Inosimudzira tendon, ligament, bone uye nyoro kuvandudzwa kwetishu, uye inogona kuwedzera angiogenesis (angiogenesis).
Kurumidza kuporeswa kwemaronda, kugadziridza mushure mekugadzirisa uye kudzoreredza kukuvara kwenyama yakapfava, iyo yakasimbiswa mumhando dzemhuka dzakadai sekuputika kwetendon, kushushikana kwemhasuru, uye kutyoka.
2. Kudzivirirwa kweGastrointestinal uye kugadzirisa
Mune mhando dzakadai segastric ulcer, enteritis, uye colitis, BPC-157 ine yakakosha mucosal kudzivirira maitiro.
Inogona kurwisa gastrointestinal kukuvara kunokonzerwa nenonsteroidal anti-inflammatory drugs (NSAIDs) uye kukurudzira intestinal mucosal kuporesa.
3. Anti-inflammatory uye immunomodulatory
Inogadzirisa kuenzana kwemaitiro ekudzivirira muviri nekudzivisa pro-inflammatory zvinhu (zvakadai seTNF-α, IL-6) uye kusimudzira zvinhu zvinopesana nekuputika.
Iine kukosha kwakakosha semubatsiri wekurapa kwezvirwere zvisingaperi zvinopisa senge ** rheumatoid arthritis uye kuzvimba bowel chirwere (IBD) **.
4. Neuroprotection uye neurogeneration
Mumienzaniso mushure mekukuvara kwemusana, nerve contusion, uye zviitiko zvecerebrovascular, BPC-157 inogona kukurudzira kuvandudzwa kwetsinga uye kuderedza kukuvara kwetsinga.
Inogona kurwisa matambudziko ari munharaunda yeurouropsychiatric senge kusagadzikana, kushushikana, uye kutsamira nedoro (yekuyedza nhanho).
5. Cardiovascular and vascular protection
BPC-157 inogona kuvandudza vascular permeability uye kukurudzira kugadzirisa microvascular, uye inotendwa kuva nemigumisiro yakanaka pazvirwere zvakadai semyocardial ischemia, venous thrombosis, uye arterial kukuvara.
Maedzo uye preclinical tsvakiridzo mhedzisiro
Kunyange zvazvo BPC-157 isati yave yakagamuchirwa zvakanyanya kumishonga yevanhu, yakaratidza mukuedza kwemhuka:
Kukurumidzira kwakakura kwenguva yekugadzira matishu (yakadai se50% kukurumidza kwekupora tendon)
Zvinonyanya kuderedza chiitiko chekubuda ropa mudumbu, kukuvara kwematumbo, uye maronda emakoloni
Kuvandudza nerve conduction kudzoreredza uye kuwedzera basa renzvimbo isina kuvharwa
Wedzera angiogenesis uye granulation tissue formation rate
Nekuda kwemhedzisiro iyi, BPC-157 yave kuita yakakosha yekutsvagisa morekuru muminda yezvekushungurudzika kwekudzoreredza, kukuvara kwemitambo, zvirwere zvemudumbu, uye neurodegenerative zvirwere.
Kugadzirwa kweAPI uye kutonga kwemhando
Iyo BPC-157 API yakapihwa neGentolex Group yedu inotora yakasimba phase synthesis (SPPS) maitiro uye inogadzirwa pasi pemamiriro eGMP. Iine maitiro anotevera:
Kuchena kwepamusoro: ≥99% (HPLC kuonekwa)
Yakaderera tsvina yakasara, hapana endotoxin, hapana inorema simbi kusvibiswa
Batch kugadzikana, kudzokorora kwakasimba, kutsigira jekiseni nhanho kushandiswa
Tsigira giremu uye kilogiramu nhanho yekupa kuti isangane nezvinodiwa zvematanho akasiyana kubva kuR&D kusvika kumaindasitiri.
