Caspofungin yeAntifungal Infections
Product Detail
| Zita | Caspofungin |
| CAS nhamba | 162808-62-0 |
| Molecular formula | C52H88N10O15 |
| Molecular uremu | 1093.31 |
| Nhamba yeEINECS | 1806241-263-5 |
| Boiling point | 1408.1±65.0 °C (Zvakafanotaurwa) |
| Density | 1.36±0.1 g/cm3(Zvakafanotaurwa) |
| Acidity coefficient | (pKa) 9.86±0.26 (Zvakafanotaurwa) |
Mashoko anoreva zvakafanana
CS-1171;Caspofungine;CASPOFUNGIN;CASPORFUNGIN;PneuMocandinB0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl -1-oxotetradecyl) -4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;CaspofunginMK-0991;Aids058650;Aids-058650
Chemical Properties
Caspofungin ndiyo yekutanga echinocandin yakabvumidzwa kurapwa kwehutachiona hwefungal. In vitro uye in vivo zviedzo zvakasimbisa kuti caspofungin ine yakanaka antibacterial chiitiko kurwisa akakosha mukana utachiona-Candida neAspergillus. Caspofungin inogona kuputsa rusvingo rwesero nekudzivisa kuumbwa kwe1,3-β-glucan. Mumakiriniki, caspofungin ine mhedzisiro yakanaka pakurapa kwakasiyana candidiasis uye aspergillosis.
Mhedzisiro
(1,3) -D-glucan synthase chinhu chakakosha chefungal cell wall synthesis, uye caspofungin inogona kuita antifungal mhedzisiro nekusakwikwidza nekudzivisa iyi enzyme. Mushure mekutonga kwemutsinga, iyo plasma zvinodhaka zvinodhaka zvinodonha nekukurumidza nekuda kwekuparadzirwa kwetishu, zvichiteverwa nekuburitswa zvishoma nezvishoma kwemushonga kubva munyama. Metabolism ye caspofungin yakawedzera nekuwedzera kwedosi uye yaive yakabatana nedosi panguva yekudzikama mamiriro neakawanda madosi. Nokudaro, kuitira kuti uwane maitiro ekurapa anobudirira uye kudzivisa kuunganidza zvinodhaka, yekutanga kurodha dose inofanira kutungamirirwa inoteverwa nechiyero chekuchengetedza. Paunenge uchishandisa cytochrome p4503A4 inducers panguva imwe chete, yakadai se rifampicin, carbamazepine, dexamethasone, phenytoin, nezvimwewo, zvinokurudzirwa kuwedzera chiyero chekuchengetedza caspofungin.
Zviratidzo
FDA-inobvumirwa zviratidzo zve caspofungin zvinosanganisira: 1. Fever neutropenia: inotsanangurwa se: fever> 38 ° C neabsolute neutrophil count (ANC) ≤500 / ml, kana neANC ≤1000 / ml uye inofungidzirwa kuti inogona kuderedzwa kusvika pasi pe500 / ml. Maererano nekurudziro yeInfectious Diseases Society of America (IDSA), kunyange zvazvo varwere vane fivha inopfuurira uye neutropenia vakarapwa nemishonga inorwisa mabhakitiriya yakakura, varwere vari pangozi vachiri kukurudzirwa kushandisa empiric antifungal therapy, kusanganisira caspofungin nemamwe mishonga inorwisa fungal. . 2. Invasive candidiasis: IDSA inokurudzira echinocandins (yakadai se caspofungin) semushonga wekusarudza kwecandidemia. Inogona zvakare kushandiswa kurapa intra-abdominal abscesses, peritonitis uye zvirwere zvechipfuva zvinokonzerwa neCandida utachiona. 3. Esophageal candidiasis: Caspofungin inogona kushandiswa kurapa esophageal candidiasis kune varwere vane refractory kana kusashivirira kune mamwe marapirwo. Ongororo dzinoverengeka dzakaona kuti kurapa kwecaspofungin kwakafanana neye fluconazole. 4. Invasive aspergillosis: Caspofungin yakabvumirwa kurapwa kweaspergillosis invasive muvarwere vane kusashivirira, kushorwa, uye kusashanda kweiyo huru antifungal drug, voriconazole. Zvisinei, echinocandin haina kukurudzirwa seyokutanga-mutsara therapy.
