Caspofungin yeAntiFaral Zvikonzero
Chigadzirwa Chinhu
| Zita | Caspofungin |
| Nhamba | 162808-62-0 |
| Molecular Formula | C52H88N1015 |
| Sreek inoremerwa | 1093.31 |
| Einecs nhamba | 180624112-263-5 |
| Boiling Point | 1408.1 × 65.0 ° C (yakafanotaura) |
| Density | 1.36 ± 0.1 g / cm3 (yakafungidzira) |
| Acidity coefficient | (pka) 9.86 ± 0.26 (yakafanotaura) |
Synonyms
CS-1171; Caspoftine; Caspofungin; Casporfungin; pneumocandinb0,1 - [(4: ((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((((1)] -1-oxotradecyl) -4-hydroxy-l-ornithine] -5 - [(((((((
Zvemakemikari zvivakwa
Caspofungin ndiyo yekutanga Echinocandin inotenderwa kurapwa kwekutapirwa kwefungidziro. MuVitro uye muVivoedzo yeVivo yakasimbisa kuti caspofugin ine yakanaka antibacterial chiitiko kumisikidza mikova yakakosha mukana - Candida naAspergillus. Caspofungin inogona kubvisa madziro eCell nekudzivisa iyo synthesis ye 1,3-β-glucan. Clinically, caspofungin ine yakanaka mhedzisiro pakurapwa kwewakasiyana-siyana candidiasis uye aspergillosis.
Maitiro
. Mushure mekutonga kweBlavento, iyo Plasma Drapt Interturity inodonhedza nekukurumidza nekuda kwekugoverwa kwematehwe, ichiteverwa nekuriritira kwemushonga kubva kumisungo kubva kumisungo. Metabolism yeCaspofungin yakawedzera neinowedzera dosi uye yaive dofo-inoenderana nenguva yekutsiga ine madhiri mazhinji. Naizvozvo, kuitira kuti uwane zviyero zvinobudirira zvinobudirira uye dzivisa kuunganidzwa kwezvinodhaka, iyo yekutanga yekutakura dhizi inofanira kutungamirwa ichiteverwa neicho chirongwa chekugadzirisa. Paunenge uchishandisa Cytochrome P4503a4 Inducers panguva imwe chete, yakadai saRifuampin, Carbamazepine, Dexamethosone, phenytoin, etc., inokurudzirwa kuwedzera iyo yekugadzirisa dhicpofugin.
Zviratidzo
FDE-Yakatenderwa Zviratidzo zveCaspoftin inosanganisira: 1. Fever neNeutropenia: Fever> ANC) ≤500 / ML ≤1000 / ml Maererano nekurudziro yeiyo nzira dzinotapukira dzeAmerican (IDSA), kunyangwe varwere vane chirwere zvehutachiona vakaremara vakarongeka . 2.. Inogona zvakare kushandiswa kurapa intra-mudumbu mabudiki, peritonitis uye hutachiona hwechipfuva hwakakonzerwa neketapuro. 3. Esophageal Candidiasis: Caspofungin inogona kushandiswa kurapa Esophageal canddiaSis mune varwere vane Refractory kana kusashivirira kune mamwe marapirwo. Zvidzidzo zvakati wandei zvakawana kuti iyo yekurapa mhedzisiro yeaspofungin yakafanana neiyo yeFluConzole. 4 Nekudaro, Echinocandin haina kukurudzirwa seyekutanga-mutsara kurapwa.
