Daptomycin 103060-53-3 yeZvirwere Zvinotapukira
Product Detail
| Zita | Daptomycin |
| CAS nhamba | 103060-53-3 |
| Molecular formula | C72H101N17O26 |
| Molecular uremu | 1620.67 |
| Nhamba yeEINECS | 600-389-2 |
| Melting point | 202-204°C |
| Boiling point | 2078.2±65.0 °C (Zvakafanotaurwa) |
| Density | 1.45±0.1 g/cm3(Zvakafanotaurwa) |
| Flash point | 87℃ |
| Kuchengetedza mamiriro | Yakavharwa pakaoma, Chengetedza mufiriji, pasi pe -20°C |
| Solubility | Methanol: soluble5mg/mL |
| Acidity coefficient | (pKa) 4.00±0.10 (Zvakafanotaurwa) |
| Form | upfu |
| Color | isina ruvara kusvika kufenda yero |
Mashoko anoreva zvakafanana
N-[N-(1-Oxodecyl)-L-Trp-D-Asn-L-Asp-]-cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp- Gly-D-Ser-[(3R)-3-methyl-L-Glu-]-4-(2-aminophenyl)-4-oxo-L-Abu-];N-[N-Decanoyl-L-Trp- D-Asn-L-Asp-]-cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R)-3-methyl-L- Glu-]-3-(2-aminobenzoyl)-L-Ala-];N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L- α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone; DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Tsanangudzo
Mushonga unorwisa mabhakitiriya daptomycin i cyclic lipopeptide antibiotic ine chimiro chitsva chakatorwa kubva mukuvirisa muto weStreptomyces (S. reseosporus), iyo inotadzisa biosynthesis yebacterial cell wall peptidoglycan nekukanganisa kutakurwa kwemaamino acids mu membrane yesero.Kushandura zvinhu zve cytoplasmic membrane zvinogona kukanganisa bhakitiriya membrane kushanda nenzira dzakawanda uye nekukurumidza kuuraya mabhakitiriya eGram-positive.Pamusoro pekugona kwayo kuita utachiona hunoenderana nechirwere cheGram-positive, daptomycin inonyanya kukosha kune mamwe marudzi akataridza kuramba methicillin, vancomycin, uye linezolid in vitro.Iine chiitiko chine simba, uye chivakwa ichi chine zvakakosha zvakanyanya zvekiriniki kune varwere vanorwara zvakanyanya.Eosinophilic pneumonia chirwere chisingawanzo uye chakakomba chine zviratidzo zvinosanganisira fivha, kukosora, kutadza kufema, uye kunetseka kufema.
Antibacterial Effect
Daptomycin ine yakanaka bacteriostatic chiitiko kurwisa akasiyana mabhakitiriya asingaurayiwi nemishonga, akadai seMIC=0.06-0.5 μg/ml yemethicillin-resistant Staphylococcus aureus (MRSA), uye methicillin-resistant Staphylococcus aureus (MRSA).MIC=0.0625～1μg/ml yebhakitiriya, MIC=0.12～0.5μg/ml yeOxacillin-resistant Staphylococcus epidermidis, MIC=2.5μg/ml ye enterococcus inoshingirira zvakanyanya kuaminoglycoside antibiotics, MICmrBI-MICm2 yeGICm2. yeEnterococcus ndeye 0.5～1μg/ml, uye MIC yeEnterococcus inoshingirira kuglycopeptide antibiotics i1～2μg/ml.
