Chondroitin Sulfate yeKurapa kweCoronary Heart Disease, Arthritis uye Kuporeswa kweCorneal Maronda Kuchena 98%
Product Detail
| Zita | Chondroitin sulfate |
| CAS nhamba | 9007-28-7 |
| Molecular formula | C13H21NO15S |
| Molecular uremu | 463.36854 |
| Nhamba yeEINECS | 232-696-9 |
| Kunyungudika kwemvura | Soluble mumvura |
| Kuchena | 98% |
| Storage | Chengetedza pane tembiricha yenguva dzose |
| Form | Upfu |
| Color | Muchena kusvika kure-chena |
| Packing | PE bag+Aluminium bag |
Mashoko anoreva zvakafanana
poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose;chondroitinpoly sulfate;chondroitin sulfates;chondroiti sulfuricacid;chondroitin sulfuric acids;chonsurid;CSO;(5ξ) -2-(Carboxyamino)-2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose
Pharmacological Effect
Tsanangudzo
Chondroitinsulfate (CS) inonzi acidic mucopolysaccharide yakabviswa uye yakacheneswa kubva kumhuka shwashwa tishu.Chondroitin sulfate ine maitiro akasiyana-siyana akadai seA, C, D, E, H uye K. Chondroitin sulfate mumasikirwo anowanikwa mumhuka cartilage, pahuro bone, nasal bone (41% munguruve), bovine, septum yebhiza uye trachea (ine 36% kusvika 39%), mamwe matishu akadai semakumbo emakumbo, ligaments, ganda, cornea, nezvimwewo zvirimowo.Zviri mukati mehove cartilage zvakapfuma kwazvo, senge 50% kusvika 60% mu shark bone, uye ishoma kwazvo mukubatanidza tishu.
For coronary atherosclerotic chirwere, yakawedzera ropa lipids uye cholesterol, arteriosclerosis, angina pectoris, myocardial ischemia, myocardial infarction, etc. muvarwere vane chirwere chemwoyo.
Pharmacological Action
Rapamycin (RAPA) ine mhedzisiro yakafanana neFK506.Munhamba huru yemakiriniki ekuyedzwa, mhedzisiro yayo yakawanikwa inoenderana nedosi uye inodzoreredzwa, uye RAPA pamishonga yekurapa haina kuwanikwa ine yakakosha nephrotoxicity uye isina gingival hyperplasia.Iyo yakanyanya chepfu uye mhedzisiro inosanganisira: musoro, kuda kurutsa, dzungu, kubuda ropa mumhino, uye kurwadziwa kwemajoini.Murabhoritari abnormalities zvinosanganisira: thrombocytopenia, leukopenia, low hemoglobin, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, yakakwira chiropa enzymes (SGOT, SGPT), yakakwira lactate dehydrogenase, hypokalemia, Hypomagnesemia, nezvimwewo. plasma phosphate mazinga anofungidzirwa kuti akareba phosphate excretion kubva kuitsvo yakasimwa neRAPA-based immunosuppressive therapy.Kufanana nemamwe ma immunosuppressants, RAPA ine mukana wakawedzerwa wekutapukirwa, ine katsika kakanzi kekuwedzera mabayo kunyanya, asi kuitika kwezvimwe zvirwere zvinongoitika hakuna kusiyana zvakanyanya neCsA.
Toxicological Migumisiro
Chondroitin sulfate inowanikwa zvakanyanya mumunhu nemhuka cartilage tishu.Kugadzirira kwemishonga kunonyanya kuve neasomers maviri echondroitin sulfate A uye chondroitin sulfate C, uye zvinyorwa zve chondroitin sulfate mu cartilage yemhuka dzemarudzi akasiyana uye mazera akasiyana.Migumisiro yaro yemishonga ndeyotevera: chondroitin sulfate inogona kubvisa lipids uye lipoproteins muropa, kubvisa cholesterol kubva mumidziyo yeropa kumativi ose emwoyo, kudzivirira nekurapa atherosclerosis, uye kuwedzera kutendeuka kwehuwandu hwe lipids uye mafuta acids mumasero.Chondroitin sulfate inogona kunyatsodzivirira uye kubata chirwere chemwoyo.Iine anti-atherosclerosis uye anti-atherogenic plaque maitiro ekugadzirisa maitiro ekuedza arteriosclerosis;inowedzera matavi ecoronary kana collateral circulation yeatherosclerosis, uye inogona kukurumidza kuedza coronary arteriosclerosis kana embolism.Kuporesa, kuberekwa patsva uye kugadziriswa kwemyocardial necrosis kana kupera.Inogona kuwedzera biosynthesis ye cell messenger ribonucleic acid (mRNA) uye deoxyribonucleic acid (DNA) uye ine mhedzisiro yekusimudzira sero metabolism.Low anticoagulant basa.Chondroitin sulfate ine mwero anticoagulant effect, uye imwe neimwe 1 mg ye chondroitin sulfate A yakaenzana ne anticoagulant basa re 0.45U yeheparin.Iyi anticoagulant basa haibvi pane antithrombin III kuita basa rayo, inogona kuita anticoagulant basa kuburikidza neiyo fibrinogen system.Chondroitin sulfate inewo anti-inflammatory, inokurumidza kuporesa maronda uye anti-tumor madhara.
