CJC-1295

CJC-1295 API

CJC-1295inogadzirwa, tetrasubstituted peptide analogue yekukura kwehomoni inoburitsa hormone (GHRH), yakagadzirirwakukurudzira uye kuchengetedza kuvharwa kwe endogenous kukura hormone (GH). Kusiyana nechizvarwa GHRH, iyo ine hafu yeupenyu hupfupi, CJC-1295 inosanganisira aDrug Affinity Complex (DAC) tekinoroji, zvichiibvumira kuti isungirire kune albumin muropa uyekurebesa hafu yehupenyu hwayo kusvika kumazuva masere. Ichi chitsva chinoita CJC-1295 arefu-kuita GHRH analogueine yakakosha kugona mukatianti-kuchembera, kushomeka kwekukura, metabolic regulation, kusagadzikana-kutambisa tsandanyama, uye regenerative mushonga.

Nzira Yekuita

CJC-1295 inoshanda paGHRH receptoriri pamasero e somatotropic mu anterior pituitary gland. Basa rayo rekubereka rinotevedzera iro rekuzvarwa GHRH, asi nehafu yakawedzera hafu yehupenyu nekuda kwekugadziriswa kweDAC. Ichi chiito chakasimba chinogonesayakagadzikana pulsatile kusunungurwa kweGHuye kuwedzera kugadzirwa kweinsulin-yakafanana nekukura chinhu 1 (IGF-1).

Nzira dzakakosha dzinosanganisira:

• Kukurudzira endogenous GH secretion

• Kureba kukwidziridzwa kweIGF-1 mazinga, inotsigira anabolic mhedzisiro

• Hapana yakakosha desensitizationkana kudzikisira nekushandisa nguva dzose

• Enhanced lipolysis, protein synthesis, uye cellular regeneration

Nekuita kuti muviri wega GH uye IGF-1 nzira, CJC-1295 inodzivirira zvakawanda zvezvipingamupinyi zvine chekuita neiyo exogenous GH therapy, senge receptor desensitization uye kuchengetedzeka kunetseka.

Therapeutic Research uye Clinical Potential

1. Kushaikwa kweHormone yeKukura (GHD)

Mukutanga-chikamu chekiriniki miedzo, CJC-1295 yakaratidza:

• Kuwedzerwa kunowedzeraGHuyeIGF-1mazinga ekusvika6-10 mazuvamushure mekubayiwa kamwe chete

• Yakaderedzwajekiseni frequencyzvichienzaniswa nemazuva ese GHRH analogues kana GH jekiseni

• Kuvandudzwa kwekuteerera kwevarwere uye kugadzikana kwehomoni

2. Kuumbwa Kwemuviri uye Kuchengetedza Tsandanyama

Zvidzidzo zvemhuka uye zvevanhu zvakaratidza kuti CJC-1295:

• Anosimudzirakuonda mhasuru kuwanauyekunoderedza mafuta emuviri, kunyanya visceral mafuta

• Inosimudziranitrogen kuchengetedza uye protein synthesismune tsandanyama

• Inogona kubatsira kupora kubvasarcopeniauye mamiriro ekutambisa tsandanyama

3. Anti-Kuchembera uye Wellness Applications

Sezvo GH uye IGF-1 mazinga achiderera nezera, CJC-1295 iri kuwedzera kudzidza seanti-aging kupindiraku:

• Vandudzakurara kunakauyecircadian rhythm regulation

• Enhanceganda elasticity, bone density,uyeimmune function

• Supportsimba metabolismuyekuneta kuramba

4. Metabolic Regulation

CJC-1295 inoratidza chivimbiso mukugadzirisainsulin kurambauye metabolic syndrome ne:

• Kuvandudzakushandiswa kweglucose

• Enhancinglipid oxidationuyeadipose tissue metabolism

• Kutsigirauremu kutarisiramuvanhu vakafuta kana vane pre-diabetic

API Kugadzira uye Kudzora Kwemhando

At Gentolex Group, zveduCJC-1295 APIinogadzirwa uchishandisasolid-phase peptide synthesis (SPPS)uye kucheneswa uchishandisa HPLC kuti uwane kuchena kwepamusoro uye batch-to-batch kuenderana.

Madiro Akakosha:

• Kuchena ≥ 99%(HPLC yakasimbiswa)

• Low residual solvents uye heavy metals

• Endotoxin-isina, isiri-immunogenic synthesis nzira

• Inowanikwa mucustom uwandu: milligram kusvika kilogram scale

Zvikumbiro uye Zvinogona Remangwana

CJC-1295 inoonekwa seimwe yeanonyanya kuvimbisa anotora nguva refu GHRH analogues, ane anogona kunyorera mu:

• Vakuru GH kushomeka kurapwa

• Body composition management mukufuta nekuchembera

• Rehabilitation kubva pakurasikirwa kwemasuru kana kukuvadzwa

• Kuita uye kudzoreredza kukwidziridzwa mumakiriniki kana emitambo marongero

• Kutsigira kurapa mukuneta kusingaperi, fibromyalgia, uye neuroendocrine kusaenzana

Kuenderera mberi miedzo yekiriniki iri kuongorora kushandiswa kwayo seimwe nzirarecombinant GH, kunyanya mukutsvaka vanhuzvakachengeteka, zvakanyanya physiological hormone modulation.