Leuprorelin Acetate Inogadzirisa Kuchengetedzwa kweGonadal Hormones
Product Detail
| Zita | Leuprorelin |
| CAS nhamba | 53714-56-0 |
| Molecular formula | C59H84N16O12 |
| Molecular uremu | 1209.4 |
| Nhamba yeEINECS | 633-395-9 |
| Kutenderera chaiko | D25 -31.7° (c = 1 mu1% acetic acid) |
| Density | 1.44±0.1 g/cm3(Zvakafanotaurwa) |
| Kuchengetedza mamiriro | -15°C |
| Form | Neat |
| Acidity coefficient | (pKa) 9.82±0.15 (Zvakafanotaurwa) |
| Kunyungudika kwemvura | Soluble mumvura pa 1mg/ml |
Mashoko anoreva zvakafanana
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINHORMELEZINGH; DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(MUNHU)
Pharmacological Effect
Leuprolide, goserelin, triprelin, uye nafarelin mishonga yakati wandei inowanzoshandiswa mukiriniki yekudzidzira kubvisa mazai ekurapwa kwegomarara rezamu rekutanga kuenda kumwedzi nekenza yeprostate.(inonzi GnRH-a mishonga), mishonga yeGnRH-a yakafanana muchimiro neGnRH uye inokwikwidza nepituitary GnRH receptors.Ndiko kuti, gonadotropin yakavanzwa nepituitary inoderera, izvo zvinotungamirira kukuderera kukuru kwehomoni yepabonde yakavanzwa ne ovary.
Leuprolide inonzi gonadotropin-releasing hormone (GnRH) analog, peptide inoumbwa ne9 amino acids.Ichi chigadzirwa chinogona kuvharidzira zvinobudirira basa repituitary-gonadal system, kushorwa kweproteolytic enzymes uye hukama kune pituitary GnRH receptor yakasimba kupfuura GnRH, uye basa rekusimudzira kuburitswa kwe luteinizing hormone (LH) inenge ka20 nguva iyoyo. yeGnRH.Iyo ine zvakare yakasimba inhibitory mhedzisiro pane pituitary-gonad basa kupfuura GnRH.Muchikamu chekutanga chekurapa, follicle stimulating hormone (FSH), LH, estrogen kana androgen inogona kuwedzerwa kwenguva pfupi, uyezve, nekuda kwekuderera kwekuteerera kwepituitary gland, kuvharidzirwa kweFSH, LH uye estrogen kana androgen kunodziviswa. zvichikonzera kuvimba nemahomoni epabonde.Zvirwere zvepabonde (zvakadai sekenza yeprostate, endometriosis, nezvimwewo) zvine maitiro ekurapa.
Parizvino, iyo acetate munyu yeleuprolide inonyanya kushandiswa kuchipatara, nekuti kuita kweleuprolide acetate kunowedzera kugadzikana pakupisa kwekamuri.Mvura inofanira kuraswa.Inogona kushandiswa kurapa kukanda kurapa kwe endometriosis uye uterine fibroids, yepakati precocious kuyaruka, premenopausal kenza yemazamu uye kenza yeprostate, uye zvakare kune inoshanda uterine kubuda ropa kunopesana kana kusashanda kune kwakajairika mahormone kurapwa.Inogonawo kushandiswa sepremedication isati yaitwa endometrial resection, iyo inogona kuenzana kutetepa endometrium, kuderedza edema, uye kuderedza kuoma kwekuvhiyiwa.
