Etelcalcetide Hydrochloride
Purogiramu inonzi Etelcalcetide Hydrochloride
Etelcalcetide Hydrochloride inyowani yakagadzirwa peptide calcimimetic yakagadzirirwa kurapwa kwechipiri hyperparathyroidism (SHPT) mune varwere vane chirwere chisingaperi cheitsvo (CKD) vari pasi pehemodialysis. SHPT inowanzoitika uye yakakomba dambudziko muvarwere veCKD, inoratidzwa nepamusoro parathyroid hormone (PTH) mazinga, yakavhiringidza calcium-phosphate metabolism, uye kuwedzera kwengozi yemapfupa uye chirwere chemwoyo.
Etelcalcetide inomiririra yechipiri-chizvarwa calcimimetic, inopihwa mukati memutsinga, uye inopa zvakanakira pamusoro pekare pakurapa nemuromo secinacalcet nekuvandudza kutevedzera uye kuderedza gastrointestinal mhedzisiro.
Nzira Yekuita
Etelcalcetide inoshanda nekusunga uye nekuita iyo calcium-sensing receptor (CaSR) iri paparathyroid gland masero. Izvi zvinotevedzera physiological mhedzisiro ye extracellular calcium, inotungamira ku:
Kudzvinyirirwa kwePTH secretion
Kuderedzwa kweserum calcium uye phosphate mazinga
Kuvandudza mineral balance uye bone metabolism
Se peptide-yakavakirwa allosteric activator yeCaSR, Etelcalcetide inoratidza yakakwirira chaiyo uye inoenderera chiitiko ichitevera intravenous kutonga post-dialysis.
Clinical Research uye Therapeutic Effect
Etelcalcetide yakaongororwa zvakanyanya muchikamu chechitatu chekiriniki miedzo, kusanganisira EVOLVE, AMPLIFY, uye EQUIP zvidzidzo. Zviwanikwa zvakakosha zvinosanganisira:
Kwakakosha uye kwakasimba kuderedzwa kwePTH mazinga muCKD varwere pahemodialysis
Kubudirira kutonga kweserum calcium uye phosphorus, inobatsira pakuvandudza bone-mineral homeostasis
Zvirinani kushivirira kana zvichienzaniswa nemuromo calcimimetics (kushoma kusvotwa uye kurutsa)
Kuvandudzwa kwekuomerera kwemurwere nekuda kwekatatu-vhiki nevhiki IV kutonga panguva yedialysis zvikamu
Aya mabhenefiti anoita kuti Etelcalcetide ive yakakosha yekurapa sarudzo yenephrologists inobata SHPT mu dialysis vanhu.
Quality uye Manufacturing
Yedu Etelcalcetide Hydrochloride API:
Inogadzirwa kuburikidza ne-soli-phase peptide synthesis (SPPS) nekuchena kwakanyanya
Inopindirana nemishonga-giredhi yakatarwa, yakakodzera kune zvinobaya majekiseni
Inoratidza mazinga akaderera ezvakasara zvinonyungudutsa, tsvina, uye endotoxins
Ino scalable yeGMP-inoenderana nehombe-batch kugadzirwa
