Terlipressin Acetate yeEsophageal Variceal Bleeding
Product Detail
| Zita | N-(N-(N-Glycylglycyl)glycyl) -8-L-lysinevasopressin |
| CAS nhamba | 14636-12-5 |
| Molecular formula | C52H74N16O15S2 |
| Molecular uremu | 1227.37 |
| Nhamba yeEINECS | 238-680-8 |
| Boiling point | 1824.0±65.0 °C (Zvakafanotaurwa) |
| Density | 1.46±0.1 g/cm3(Zvakafanotaurwa) |
| Kuchengetedza mamiriro | Gara munzvimbo ine rima, inert atmosphere, Chengetedza mufiriza, pasi pe -15°C. |
| Acidity coefficient | (pKa) 9.90±0.15 (Zvakafanotaurwa) |
Mashoko anoreva zvakafanana
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein;1-Triglycyl-8-lysineVasopressin;Nα-Glycyl-glycyl-glycyl- [8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressin.
Tsanangudzo
Terlipressin, ine zita rekemikari inonzi triglycyllysine vasopressin, chigadzirwa chitsva chenguva refu chichiita vasopressin.Imhando yeprodrug, iyo isingashande yega.Inoitwa neaminopeptidase mu vivo kuti zvishoma nezvishoma "isunungure" inoshanda lysine vasopressin mushure mekubvisa matatu glycyl asara paN-terminus yayo.Naizvozvo, terlipressin inoshanda sedhamu rinoburitsa lysine vasopressin pamwero wakatsiga.
The pharmacological effect ye terlipressin ndeyekubatirana splanchnic vascular smooth muscle uye kuderedza splanchnic blood flow (sekuderedza kuyerera kweropa mu mesentery, spleen, chibereko, nezvimwewo), nokudaro kuderedza portal blood flow uye portal pressure.Kune rumwe rutivi, inogonawo kuderedza plasma Mhedzisiro ye renin concentration, nokudaro kuwedzera kuyerera kweropa renal, kuvandudza renal basa uye kuwedzera weti kubuda kune varwere vane hepatorenal syndrome.Terlipressin parizvino ndiyo yega mushonga unogona kuvandudza mwero wekupona kwevarwere vane esophageal variceal hemorrhage.Yainyanya kushandiswa mukurapa kwekiriniki yevariceal hemorrhage.Pamusoro pezvo, terlipressin yakashandiswawo zvinobudirira muchiropa neitsvo.Kazhinji, zvinokwanisika kuita basa rinobatsira mukugarisana kwerefractory shock uye cardiopulmonary resuscitation.Kana ichienzaniswa ne vasopressin, ine simba rinogara kwenguva refu, haikonzeri matambudziko ane ngozi, anosanganisira fibrinolysis uye matambudziko akakomba mutsinga yemwoyo, uye iri nyore kushandisa (jekiseni remutsinga), iro rinonyanya kukodzera kutarisisa kwakanyanya uye kwakanyanya.Kununura uye kurapwa kwevarwere vanorwara zvakanyanya.
