Ganirelix Acetate Peptide API Featured Image

Ganirelix Acetate Peptide purogiramu

Tsanangudzo Pfupi

Zita: Ganirelix Acetate

Nhamba yeCAS: 123246-29-7

Molecular formula: C80H113ClN18O13

Molecular uremu: 1570.34

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Product Detail

Product Tags

Product Detail

Zita	Ganirelix Acetate
CAS nhamba	123246-29-7
Molecular formula	C80H113ClN18O13
Molecular uremu	1570.34

Mashoko anoreva zvakafanana

Ac-DNal-DCpa-DPal-Ser-Tyr-DHr(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate;GANIRELIX;Ganirelix Acetate USP/EP/

Tsanangudzo

Ganirelix is a synthetic decapeptide compound, uye acetate munyu, Ganirelix acetate inonzi gonadotropin-releasing hormone (GnRH) receptor antagonist.Iyo amino acid sequence ndeiyi: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro- D- Ala-NH2.Kunyanya kukiriniki, inoshandiswa muvakadzi vanobatsirwa tekinoroji yekuzvara inodzorwa ovarian kukurudzira zvirongwa kudzivirira nguva isati yakwana luteinizing mahomoni peaks uye kurapa kusagadzikana kwembereko nekuda kwechikonzero ichi.Mushonga wacho une maitiro ekusagadzikana kwakashata, kukwirira kwepamuviri uye nguva pfupi yekurapa, uye ine mabhenefiti ari pachena kana ichienzaniswa nemishonga yakafanana mukuita kwekiriniki.

Pharmacological Action

Iko pulsatile kusunungurwa kwegonadotropin-releasing hormone (GnRH) inomutsa kuumbwa uye kubudiswa kweLH neFSH.Kuwanda kweLH pulses pakati uye kunonoka follicular phases inenge 1 paawa.Aya mapurusi anoratidzwa mukukwira kwechinguvana muserum LH.Munguva yepakati-kuenda kumwedzi, kuburitswa kukuru kweGnRH kunokonzera kuvhiya kweLH.Kuvhiya kweLH yepakati pemwedzi kunogona kukonzeresa mhinduro dzakati wandei dzemuviri, kusanganisira: ovulation, oocyte meiotic resumption, uye corpus luteum formation.Kuumbwa kwecorpus luteum kunoita kuti serum progesterone mazinga akwire, nepo estradiol mazinga achidonha.Ganirelix acetate mupikisi weGnRH uyo anokwikwidza anovharira GnRH receptors papituitary gonadotrophs uye inotevera nzira dzekufambisa.Inoburitsa kukurumidza, kudzoreredzwa inhibition yegonadotropin secretion.Iyo inhibitory effect ye ganirelix acetate pane pituitary LH secretion yakanga yakasimba kudarika iyo paFSH.Ganirelix acetate yakakundikana kukurudzira kusunungurwa kwekutanga kwe endogenous gonadotropins, inopindirana nekupikisa.Kuzadza kupora kwepituitary LH neFSH mazinga kwakaitika mukati maawa makumi mana nemasere mushure mekunge ganirelix acetate yamiswa.

Zvakapfuura: Cetrorelix Acetate Kudzivirira Premature Ovulation 120287-85-6

Zvinotevera: Linaclotide yeGastrointestinal Disorders 851199-59-2

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