Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Tsvagiridzo Yekushandisa:
Mushonga uyu unodzivirirwa, unoshanda lysine derivative inoshandiswa mu peptide synthesis uye drug conjugate development. Inosanganisira Fmoc boka reN-terminal kudzivirira, uye rutivi-cheni kuchinjwa neEic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), uye AEEA (aminoethoxyethoxyacetate). Izvi zvikamu zvakagadzirirwa kudzidza lipidation mhedzisiro, spacer chemistry, uye inodzorwa kuburitswa kwezvinodhaka. Inotsvakurudzwa zvakanyanya mumamiriro ezvinhu emishonga yeprodrug, ADC linkers, uye membrane-interacting peptides.

Basa:
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH inoshanda sechivakwa chekugadzira lipid-modified peptides kana masisitimu ekutumira zvinodhaka. Iyo Eic moiety inovandudza lipophilicity uye membrane kusunga; γ-Glu inowedzera kugadzikana enzymatic uye inonongedza kugona; uye AEEA inoshanda seyakagadziriswa hydrophilic linker. Pamwe chete, ivo vanogonesa kuvakwa kwepeptides nekuwedzera cellular uptake, yakawedzera hafu yehupenyu, uye saiti-yakanangana yekuendesa zvivakwa.