Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Tsvagiridzo Yekushandisa:
Mushonga uyu wakagadziridzwa lysine derivative inoshandiswa mupeptide synthesis, kunyanya pakuvaka anonangwa kana akawanda anoshanda peptide conjugates. Boka reFmoc rinobvumira nhanho synthesis kuburikidza neFmoc solid-phase peptide synthesis (SPPS). Cheni yepadivi yakagadziridzwa ine stearic acid inotorwa (Ste), γ-glutamic acid (γ-Glu), uye maviri AEEA (aminoethoxyethoxyacetate) linkers, ayo anopa hydrophobicity, kuchaja zvivakwa, uye kuchinjika nzvimbo. Inowanzodzidzwa nezvebasa rayo muhurongwa hwekuunza zvinodhaka, kusanganisira antibody-drug conjugates (ADCs) uye cell-inopinda peptides.

Basa:
Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH inoshanda sechivako chekugadzira peptides refu-chain lipidated kana drug-linker complexes. Iyo stearic acid inowedzera membrane affinity, γ-Glu inovandudza kugadzikana uye enzymatic kuramba, uye AEEA linkers inopa solubility uye kushanduka kwemaitiro. Pamwe chete, aya maficha anoita kuti mukomboni uve wakakosha mukugadzira mapeptides ekuvandudza bioavailability, inodzorwa kuburitswa, uye yakanangwa yekutumira maapplication.