IButamoaren MIYLate inowedzera uremu hwemuviri, Serum Igf-1 uye GH mazinga
Chigadzirwa Chinhu
| Zita | Ibutamororen Mesilate |
| Nhamba | 159752-16-0 |
| Molecular Formula | C28h40n4o8s2 |
| Sreek inoremerwa | 624.77 |
| Einecs nhamba | 1308068-626-2 |
| Inonyungudika | 164-170 ° C |
| Solubility | H2O: Soluble5mg / ml, yakajeka |
| Kuchengetedza mamiriro | 2-8 ° C |
| Fomu | Poda |
| Ruvara | White kuBeige |
| Kurongedza | Pe bag + aluminium bhegi |
Synonyms
Mk-677; 2-amino-n - [(1,2-4-deslsulfonyl) Spirole-3,4-yl]-4 - akadya; mk677 (ibutamenmenylate); mk-677; crescendo; mk0677; mk-0677; mk0677; mk677; mk677; c S-1402; mk677mk677butamen; mk677mk677butamen, Whnohe_lucy (at) 163.com; mk677, mk677
Pharmacological mhedzisiro
Tsananguro
Ibramelen Mesillate mushonga uyo unoita senge ane simba, ane simba simba, kukura-kusimudzira chiganho chehormone, mitacking chiito cheGH kukurudzira mahormone eSedo.
Basa
Ibramolen Mesylate yakaratidzwa kuti iwedzere kusunungurwa uye kugadzirwa kwekuwedzera kwekuwedzera maplasma mazinga emamwe mahormone kusanganisira ghmones Zvinogona kurapwa zviri pasi pekuvandudza kuderedza mazinga eaya mahormone, vakweguru nevatengi kushomeka kwehomoni, uye zvidzidzo zvevanhu zvakaratidza kushomeka uye pfupa density, kuzviita kurapwa kwekuvimbisa kwevakuru vakura. Izvo zvakare zvinoshandura metabolism yemafuta emuviri, saka zvinogona kunge zvine manyorero mukurapa kwekufutisa.
MuVivo Zvidzidzo
Ibutamoren MIYLate (5 mg / kg / zuva) inoguma yakakura yakakosha inowedzera uremu hwemuviri uwane uye inowedzera serum igf-1 uye gh mazinga muimbwa. Ibutamororen MIYTLate anowana mukuwedzera kwakakosha muCSF igf-1 kana gh mazinga pamazuva manomwe kana gumi nemashanu ekudzidza. Kufungidzira makonzo ane GH maburi activation yeaya neurons naIbutamen Mesylate (50 μg, ip). Mukugogodza makonzo, mese gh uye ocseotide inotadza kuIting Ibitamoaren mesylate activation yeArcuate neurons. Chekurapa chomutsa mhou Iyo gh profile inotevera Mk-0677 maneja anoenderana neEpisodic inowedzera pamusoro pekudzora. Mk-0677 zvakanyanya kuwedzera peak gh kuvanzika mushure memuromo maneera. MK-0677 ndeyekuchengetedzeka kweGhitagogue uyo anokurudzira pakarepo, hombe, refu, refu nguva yekuwedzera mumazinga eGH kana wakatungamirwa nemuromo kana iv
