Ipamorelin
Ipamorelin API
Ipamorelin is a synthetic pentapeptide growth hormone releasing peptide (GHRP) inoumbwa neamino acids mashanu (Aib-His-D-2-Nal-D-Phe-Ls-NH₂). Iyo inosarudza GHSR-1a agonist ine simba rekukurudzira kukura kwehomoni (GH) secretion nehupamhi hwepamusoro. Kuenzaniswa neGHRPs yekare (yakadai seGHRP-2 uye GHRP-6), Ipamorelin inoratidza zviri nani kusarudza, kuchengeteka uye kugadzikana kwemishonga pasina kukanganisa zvakanyanya mazinga emamwe mahomoni akadai se cortisol, prolactin kana ACTH.
Seyakanyanya kutariswa peptide API, Ipamorelin ikozvino inoshandiswa zvakanyanya mukurwisa-kukwegura tsvakurudzo, kugadziriswa kwemitambo, kupindira kweosteoporosis, postoperative recovery uye metabolic function regulation.
Tsvagiridzo uye Mechanism Yekuita
Ipamorelin inokurudzira kusunungurwa kwe endogenous growth hormone (GH) kubva kune anterior pituitary nekusarudza kushandiswa kwekukura kwehomoni secretion receptor (GHSR-1a) uye kutevedzera chiito cheghrelin. Yayo huru yemishonga nzira dzinosanganisira:
1. Kurudzira GH secretion
Ipamorelin inonyanya kusarudzwa inofadza GHSR-1a, ichiita kuti pituitary gland isunungure GH pasina kunyanya kukanganisa ACTH kana cortisol mazinga, uye ine zviri nani endocrine kuchengeteka.
2. Kuvandudza mapuroteni synthesis uye kugadzirisa masero
Nekuwedzera IGF-1 mazinga, inosimudzira tsandanyama cell anabolism, inosimudzira kugadziriswa kwematishu uye kuvandudzwa, uye inokodzera kugadziriswa kwekukuvara, kuvhiya kupora uye anti-muscle atrophy kurapwa.
3. Kuvandudza metabolism uye kugoverwa kwemafuta
GH ine mhedzisiro yekuunganidza mafuta uye insulin senitivity kuvandudzwa. Ipamorelin inogona kubatsira mukugadzirisa mamiriro emagetsi uye inoshandiswa mukutsvakurudza pamusoro pe metabolic syndrome uye kupindira kwekufutisa.
4. Kuvandudza kusimba kwemapfupa uye kurwisa kukwegura
GH/IGF-1 axis inogona kukurudzira kuumbwa kwemapfupa uye mineralization. Ipamorelin inoratidza chivimbiso mu-anti-osteoporosis, fracture rehabilitation uye anti-aging.
5. Kuvandudza circadian rhythm uye kunaka kwekurara
GH kusunungurwa kunowanzoperekedzwa nehope huru. Zvidzidzo zvakawana kuti Ipamorelin inogona kuvandudza zvimiro zvekurara uye kuvandudza kugona kwemuviri kupora.
Preclinical zvidzidzo uye efficacy verification
Kunyange zvazvo ichiri mu preclinical / kliniki yekutanga, Ipamorelin yakaratidza kuchengeteka kwakanaka uye kubudirira mumhuka uye zvimwe zvidzidzo zvevanhu:
GH mazinga akawedzera zvakanyanya (peak mukati me30 maminetsi, anogara kwemaawa akati wandei)
Hapana pachena pro-cortisol kana pro-ACTH mhedzisiro, endocrine mhedzisiro inodzoreka
Kuvandudza mhasuru uye simba (kunyanya mumhando dzemhuka dzechikuru)
Kuvandudza postoperative kupora uye kukurumidza kugadzirisa tishu
Yakawedzera IGF-1 mazinga anobatsira sero kugadzirisa uye antioxidant mhinduro
Mukuwedzera, Ipamorelin yakasanganiswa nedzimwe GHRH mimetics (yakadai seCJC-1295) mune zvimwe zvidzidzo zvakaratidza synergistic madhara, zvichiwedzera kuwedzera kusunungurwa kweGH.
API kugadzirwa uye kuvimbiswa kwemhando
Ipamorelin API inopiwa neGentolex Group yedu inogadzirirwa kushandiswa kwepamusoro-soro ** solid phase peptide synthesis process (SPPS) **, uye yakanyatsocheneswa uye yakaedzwa kunaka, yakakodzera kutsvakurudza kwesayenzi nekusimudzira uye kushandiswa kwepombi yekutanga kwemakambani emishonga.
Zvigadzirwa zvechigadzirwa zvinosanganisira:
Kuchena ≥99% (HPLC bvunzo)
Hapana endotoxin, yakaderera yakasara solvent, yakaderera simbi ion kusvibiswa
Ipa iyo yakazara seti yemhando magwaro: COA, kugadzikana chidzidzo chirevo, kusachena spectrum ongororo, nezvimwe.
Customizable gram-level ~ kilogram-level supply
