Leuprorelin Acetate Inogadzirisa Secretion yeGonadal Hormones
Product Detail
| Zita | Leuprorelin |
| CAS nhamba | 53714-56-0 |
| Molecular formula | C59H84N16O12 |
| Molecular uremu | 1209.4 |
| Nhamba yeEINECS | 633-395-9 |
| Kutenderera chaiko | D25 -31.7° (c = 1 mu1% acetic acid) |
| Density | 1.44±0.1 g/cm3(Zvakafanotaurwa) |
| Kuchengetedza mamiriro | -15°C |
| Form | Neat |
| Acidity coefficient | (pKa) 9.82±0.15 (Zvakafanotaurwa) |
| Kunyungudika kwemvura | Soluble mumvura pa 1mg/ml |
Mashoko anoreva zvakafanana
LH-RHLEUPROLIDE;LEUPROLIDE;LEUPROLIDE(HUMAN);LEUPRORELIN;[DES-GLY10,D-LEU6,PRO-NHET9]-LUTEINIZINGHORMONE-RELEASINGHORMONEHUMAN;(DES-GLY10,D-LEU6,PRO -NHET9)-LUTEINIZINGHORMONE-RELEASINGHORMONE;(DES-GLY10,D-LEU6,PRO-NHET9)-LUTEINIZINGHORMONE-RELEASINGFACTOR;[DES-GLY10,D-LEU6,PRO-NHET9]-LH-RH(MUNHU)
Pharmacological Effect
Leuprolide, goserelin, triprelin, uye nafarelin mishonga yakati wandei inowanzoshandiswa mukiriniki yekudzidzira kubvisa mazai ekurapa premenopausal remazamu nekenza yeprostate. (inonzi GnRH-a mishonga), mishonga yeGnRH-a yakafanana muchimiro neGnRH uye inokwikwidzana nepituitary GnRH receptors. Ndiko kuti, gonadotropin yakavanzwa nepituitary inoderera, izvo zvinotungamirira kukuderera kukuru kwehomoni yepabonde yakavanzwa ne ovary.
Leuprolide inonzi gonadotropin-releasing hormone (GnRH) analog, peptide inoumbwa ne9 amino acids. Ichi chigadzirwa chinogona kuvharidzira zvinobudirira basa repituitary-gonadal system, kushorwa kweproteolytic enzymes uye hukama kune pituitary GnRH receptor yakasimba kupfuura GnRH, uye basa rekusimudzira kuburitswa kwe luteinizing hormone (LH) inenge 20 nguva yeGnRH. Iyo ine zvakare yakasimba inhibitory mhedzisiro pane pituitary-gonad basa kupfuura GnRH. Muchikamu chekutanga chekurapa, follicle stimulating hormone (FSH), LH, estrogen kana androgen inogona kuwedzerwa kwekanguva, uyezve, nekuda kwekuderera kwekuteerera kwepituitary gland, secretion yeFSH, LH uye estrogen kana androgen inodziviswa, zvichiita kuti pave nekuvimba nehomoni dzepabonde. Zvirwere zvepabonde (zvakadai sekenza yeprostate, endometriosis, nezvimwewo) zvine maitiro ekurapa.
Parizvino, iyo acetate munyu ye leuprolide inonyanya kushandiswa kuchipatara, nokuti kushanda kwe leuprolide acetate kunowedzera kugadzikana pakupisa kwekamuri. Mvura inofanira kuraswa. Inogona kushandiswa kurapa kukanda kurapa kwe endometriosis uye uterine fibroids, yepakati precocious kuyaruka, premenopausal kenza yemazamu uye kenza yeprostate, uye zvakare kune inoshanda uterine kubuda ropa kunopesana kana kusashanda kune kwakajairika mahormone kurapwa. Inogonawo kushandiswa sepremedication isati yaitwa endometrial resection, iyo inogona zvakaenzana kutetepa endometrium, kuderedza edema, uye kuderedza kuoma kwekuvhiyiwa.
