GH/IGF-1 inoderera physiologically nezera, uye shanduko idzi dzinoperekedzwa nekuneta, tsandanyama atrophy, yakawedzera adipose tishu, uye kuderera kwekuziva kune vakwegura…
Muna 1990, Rudman akabudisa pepa muNew England Journal of Medicine iyo yakashamisa munharaunda yezvokurapa - "Kushandiswa kweHuman Growth Hormone muVanhu Vanopfuura 60 Makore Ezera".Rudman akasarudza varume gumi nevaviri vane makore 61-81 kumakiriniki miedzo:
Mushure memwedzi ye6 yehGH jekiseni, zvidzidzo zvaive neavhareji yekuwedzera kwe8.8% muhuturu, 14.4% mukurasikirwa kwemafuta, 7.11% mukukura kweganda, 1.6% mumapfupa emapfupa, 19% muchiropa uye 17% muspleen kana ichienzaniswa nekutonga. boka revamwe vanhu vakwegura vezera rimwe chete.%, zvakagumiswa kuti shanduko yehistological muzvidzidzo zvese yaive makore gumi kusvika makumi maviri.
Mhedziso iyi yakatungamira kusimudzirwa kwakapararira kweiyo recombinant human growth hormone (rhGH) semushonga unorwisa kuchembera, uye zvakare ndicho chikonzero chekutenda kwevanhu vazhinji kuti jekiseni reRhGH rinogona kurwisa kuchembera.Kubva ipapo, varapi vazhinji vakashandisa hGH semushonga unopesana nekuchembera, kunyangwe isina kubvumidzwa neFDA.
Zvisinei, sezvo tsvakurudzo ichiri kuramba ichidzika, masayendisiti akawana kuti zvikomborero zvishoma kumuviri wekuwedzera basa reGH / IGF-1 axis hazvireve hupenyu hwevakwegura, asi panzvimbo pezvo zvinoisa hutano hwehutano:
Mice oversecreting GH yakakura, asi ine 30% -40% nguva pfupi yehupenyu kupfuura mhuka dzomusango [2], uye histopathological changes (glomerulosclerosis uye hepatocyte proliferation) inoitika mumakonzo ane mazinga akakwirira eGH.hombe) uye insulin kuramba.
Mazinga akakwirira eGH anokurudzira kukura kwemisungo, mapfupa, uye nhengo dzomukati, zvichiita kuti gigantism (muvana) uye acromegaly (muvanhu vakuru).Vakuru vane GH yakawandisa vanowanzobatanidzwa nechirwere cheshuga uye matambudziko emwoyo, pamwe chete nehuwandu hwekenza.
Nguva yekutumira: Jul-22-2022