Pegcetacoplan

Purogiramu inonzi Pegcetacoplan

Pegcetacoplan inonzi pegylated cyclic peptide inoshanda seyakanangwa C3 complement inhibitor, yakagadzirirwa kurapwa kwezvirwere zvinopindirana zvakadai separoxysmal nocturnal hemoglobinuria (PNH) uye geographic atrophy (GA) muzera remacular degeneration.

Mechanism & Tsvagiridzo:
Pegcetacoplan inosunga kuzadzisa mapuroteni C3 neC3b, kudzivirira kushandiswa kweiyo inopindirana cascade. Izvi zvinoderedza:
Hemolysis uye kuzvimba muPNH
Retinal cell kukuvara mune geographic atrophy
Immune-mediated tishu kukuvara mune mamwe matambudziko anofambiswa-anofambiswa