Rapamycincincin in @munosuppressive mushonga, anti-cancer uye anti-kukwira
Chigadzirwa Chinhu
| Zita | Rapamycin |
| Nhamba | 53123-88-9 |
| Molecular Formula | C51H79No13 |
| Sreek inoremerwa | 914.19 |
| Einecs nhamba | 610-965-5 |
| Boiling Point | 799.83 ° C (yakafanotaura) |
| Density | 1.0352 |
| Kuchengetedza mamiriro | Chisimbiso mune chakaoma, chengetedza mu freezer, pasi pe -20 ° C |
| Fomu | Poda |
| Ruvara | Chena |
| Kurongedza | Pe bag + aluminium bhegi |
Synonyms
Ay 22989; 23,27-epoxy-3h-pildo (2,1-pyrido (1,4) OxaazcyClootine; rapa; rapamycin, striptomycess hygroscopicus; rpm
Pharmacological mhedzisiro
Tsananguro
Rapamycin masacrodide antibiotic iyo yakarongeka yakafanana neProcofol (FK506), asi ine yakasarudzika yakakwana immunosuppress mechanism. FK506 inhibits the prolife University of Chicago Vaongorori veChicago vanoshandisa maratidziro ezvekutengesa rapamycin. Zvidzidzo zvakaratidza kuti Rapamycin inobhadharwa nyore nyore nema enzymes mushure mekupinda muturikiti yekugaya, uye muto wemazamu ane huwandu hwakawanda hweFuronox, iyo inogona kukanganisa mari yekubvisa turakiti enzymes pane rapamycin. Inogona kuvandudza bioavailility yeRapamycin. Zvinonzi vanachiremba vekutanga veDutch vakawana kuti muto wemazambiringa ane mhedzisiro yekuvandudza kurambidza kwekusanzwisiswa kwekununura
Mumakore achangopfuura, zvidzidzo zvakawana kuti chinangwa cheRapamycin (mtor) inguva yemukati moti, uye kusingaenzaniswi kweiyo nzira yayo yekubata kunogona kuunza akasiyana siyana ezvirwere zvakasiyana siyana. Semunhu anenge atariswa anonzi Mtor, Rapamycin anogona kubata matsvina padhuze nenzira iyi, kusanganisira Renal cancer, lymphoma, chirwere chegomarara, kenza yemazamu, negomarara remazamu uye kenza yegomarara. Kunyanya mukurapa kwezvirwere zviviri zvisingawanzo, lam (Lymphangiomyomatosis) uye tsc (tumpus sclerosis), mhedzisiro iri pachena, uye lam naTsc inogona zvakare kutaridzika seyechirwere kusvika padanho.
Mhedzisiro
Rapamycin (rapa) ine mhedzisiro yakafanana neFK506. Muhuwandu hukuru hwemiyedzo miedzo, mhedzisiro yaro yakawanikwa kuti iitwe-inotsamira uye inotsauka, uye rapa madhiri ekurapa haana kuwanikwa kuti ave neakakosha uye hapana ginperplasia. Iyo huru ine chepfu uye mhedzisiro inosanganisira: Musoro, kusvotwa, kuderera, mhodzi, uye marwadzo. Laboratory Abnormalities inosanganisira: Lukopenia, Hyperchlescemia, HypercholesteMia, HyperchlesteMia (Sgpolaillesteero dehydrogease, Hypokleste dehydrogease, hypokallemia NaRapa Administration, uye chikonzero chezasi Plasma Level Kufanana nedzimwe immunosupppress, rapa ine mukana wekutapukirwa, nemukana wekutaurwa kuti uwedzere kuwedzera pneumonia kunyanya, asi kuitika kweimwe hutachiona hutsinye hauna kusiyana zvakanyanya neCSA.
