Sildenafil Citrate Kurapa Erectile Dysfunction 171599-83-0
Product Detail
| Zita | Sildenafil Citrate |
| CAS nhamba | 171599-83-0 |
| Molecular formula | C28H38N6O11S |
| Molecular uremu | 666.70 |
| Nhamba yeEINECS | 200-659-6 |
| Merck | 14,8489 |
| Density | 1.445g/cm3 |
| Kuchengetedza mamiriro | 2-8°C |
| Form | Upfu |
| Color | Chena |
| Kunyungudika kwemvura | DMSO:> 20mg/mL |
Mashoko anoreva zvakafanana
Viagra,Sildenafil citrate; 1- [[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitratesalt; 5- [2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-onecitratesalt; 1- [[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate(100mg); Sildenafilcitrate,>=99%;Sildenafilcitrate,Professionalsupply; 5--[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-onecitrate
Pharmacological Effect
Pharmacological Action
Sildenafil citrate is selective 5-phosphodiesterase inhibitor inowedzera nitric oxide-dependent, cyclic guanosine monophosphate-mediated pulmonary vasodilation nekudzivisa kuparara kwecyclic guanosine monophosphate. Mukuwedzera kune kuwedzera kwakananga kwemidziyo yeropa yemapapu, inogonawo kudzivirira kana kudzorerazve vascular remodeling.
Mishonga Properties uye Applications
Sildenafil citrate, zita rekutengeserana Viagre, rinowanzozivikanwa seViagra, inonzi cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5) inhibitor inogona kuwedzera erection mushure mekutonga kwemuromo. Sildenafil citrate inogona kuwedzera simba re nitric oxide (NO) nekudzivisa rudzi rwe 5 phosphodiesterase iyo inoparadza cyclic guanosine monophosphate (cGMP) mu corpus cavernosum. Wedzera chiyero che cGMP mu corpus cavernosum, zorora musuru wakatsetseka mu corpus cavernosum, kuwedzera kubuda kweropa, kurebesa penis erection nguva uye kuwedzera kusimba. Kune varwere vasina simba vane erectile dysfunction. Vakuru vanotora 50 mg nemuromo nguva imwe neimwe, kusvika ku1 nguva pazuva, uye vashandise sezvinodiwa nezve 1 awa vasati vaita zvepabonde. Iyo yakawanda yakawanda ndeye 0.1g nguva imwe neimwe.
In vivo zvidzidzo
Mune imbwa dzine anesthetized, Sildenafil citrate inowedzera penile erectile basa pasi pepelvic nerve stimulation nekuyera intracavernous pressure. Sildenafil citrate yakanyatso kudzoreredza kusagadzikana kwecarbamoylcholine-inosimudzira kuzorora uye inhibited superoxide kuumbwa mune cavernosal tishu ye hypercholesterolemic tsuro. Mumakonzo eSprague-Dawley, Sildenafil inovandudza erectile basa mune imwe nguva-inotenderera-inotenderera, pamwe nekupora kwakanyanya kunoitika pazuva 28 pachiyero che20 mg / kg pazuva. Mumakonzo eSprague-Dawley, kutonga kweSildenafil kwakakonzera kuchengetedzwa kwemhasuru collagen chiyero kuchengetedza uye kuchengetedzwa kweCD31 uye eNOS kutaura. MuSprague-Dawley rats, Sildenafil yakaderedza zvakanyanya apoptotic index uye yakawedzera phosphorylation ye akt uye eNOS kana ichienzaniswa neboka rinodzora.
