Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU

Ste-γ-Glu-AEEA-AEEA-OSU inogadzira lipidated linker molecule yakagadzirirwa kuendeswa kwezvinodhaka uye antibody-drug conjugates (ADCs). Iyo inoratidzira stearoyl (Ste) hydrophobic muswe, γ-glutamyl inonangisa motif, AEEA spacers yekuchinjika, uye OSu (NHS ester) boka rekubatana kwakanaka.

 
Tsvagiridzo & Zvishandiso:

Inoshandiswa mune yakanangwa prodrug synthesis uye nanocarrier dhizaini

Inovandudza kupindirana kwesero membrane uye kutora zvinodhaka

Inofambisa saiti-yakananga payload yekunamatira kune peptides, masoja ekudzivirira chirwere, kana vatakuri

Zvigadzirwa zvechigadzirwa (Gentolex Boka):

Kuchena kwepamusoro, kugadzirira-ku-conjugate NHS ester

Inokodzera bioconjugation uye yakanangwa yekuendesa tsvagiridzo

Ste-γ-Glu-AEEA-AEEA-OSU yakanakira kugadzirwa kwechirongwa chekuburitsa zvinodhaka.