Tianeptine sodium yeshoko rinoshungurudza

Kushandiswa

Izvo zvinonyanya kuita pane 5-HT system, pasina kufara, sedation, anti-acetylcholine uye cardioxicity. Kushungurudzika.

Pharmacological mhedzisiro

1. Iyo anderepressant maitiro echigadzirwa ichi akasiyana neiyo yetsika tca. Inogona kuwedzera iyo inokwira ye5-ht mune synaptic cleft, asi ine simba risinganyariki pane kusashandurazve kwe5-ht na na. Inogona kunge iine mhedzisiro yekuvandudza 5-ht neuronal kutapurirana. Izvo hazvina kushamwaridzana kwema m receptors, H1, α1 na α2-na Receptors.
2. Kubudirira kweAndidepress Iko kushanda kwechigadzirwa ichi kwakafanana neiyo yeSSRI Fluoxetine.
3. Mhuka inodhaka yakaratidza kuti inogona: Wedzera chiitiko chinongoitika chePiramidhi masero mumvuvuu muhuvhu uye nekumhanyisa kudzoreredzwa kwebasa rayo mushure mekunzwa. Wedzera iyo reabsorption ye5-hydroxytryptamine neNeurons mune cerebral cortex neHippocampus.

Toicology zvidzidzo

- Acute, Subachute uye yakareba-refu-testity testity bvunzo: Hapana shanduko mu biology, chiropa basa, pathological anatomy.
- Kubereka Thupfu uye Teratogenicity Test: Tianeptine haina chekuita nekugona kubereka kwevabereki vakabatwa uye pane fetus uye mwana.
- MutageniCity Test: Tianeptine haina mu mumagenic maitiro.