Tirzepatide

Purogiramu inonzi Tirzepatide
Tirzepatide inonzi groundbreaking synthetic peptide inoshanda seaviri agonist yeglucose-inotsamira insulinotropic polypeptide (GIP) uye glucagon-like peptide-1 (GLP-1) receptors. Inomiririra kirasi itsva ye incretin-based therapies inozivikanwa se "twincretins", inopa yakawedzera metabolic control kune varwere vane Type 2 chirwere cheshuga uye kufutisa.

Yedu Tirzepatide API inogadzirwa kuburikidza nemhando yepamusoro kemikari synthesis matekiniki, kuve nechokwadi chepamusoro kuchena, kuderera kwehutsvina mazinga, uye yakanakisa batch-kune-batch kuenderana. Kusiyana nerDNA-yakatorwa peptides, yedu yekugadzira API haina kubva kune anotambira maseru mapuroteni uye DNA, zvakanyanya kunatsiridza biosafety uye kutevedzera mutemo. Maitiro ekugadzira akagadziridzwa kuti akwire-kumusoro kusangana nekukura kuri kuda kwepasirese.

Nzira Yekuita
Tirzepatide inoshanda nekukurudzira panguva imwe chete ese GIP uye GLP-1 receptors, ichipa inopindirana uye synergistic mhedzisiro:

GIP receptor activation: inowedzera insulin secretion uye inogona kuvandudza insulin senitivity.

GLP-1 receptor activation: inodzvanya kuburitswa kweglucagon, inononoka kubuda mudumbu, uye inoderedza kudya.

Chiitiko chakasanganiswa chinotungamira ku:

Kuvandudza glycemic control

Kuderera kwehuremu hwemuviri

Kuwedzerwa kuguta uye kuderedza kudya kwekudya

Clinical Research & Migumisiro
Tirzepatide yakaratidza kushanda kusati kwamboitika mune akawanda mahombe ekiriniki miedzo (SURPASS & SURMOUNT akatevedzana):

Superior HbA1c kuderedza ichienzaniswa neGLP-1 RAs (semuenzaniso, Semaglutide)

Kurasikirwa kwehuremu kusvika ku22.5% muvarwere vakafuta - kuenzaniswa nekuvhiyiwa kwebariatric mune dzimwe nguva

Kurumidza kutanga kwemhedzisiro uye yakasimba glycemic control pamusoro pekushandiswa kwenguva refu

Yakavandudzwa cardiometabolic mamaki: anosanganisira BP, lipids, uye kuzvimba

Tirzepatide haisi kungogadzirisa paradigm yekurapa kwechirwere cheshuga chechipiri asi zvakare kubuda senzira huru yekurapa yekurasikirwa nehuremu hwekurapa uye metabolic syndrome.

Hunhu & Kutevedzera
Purogiramu yedu yeTirzepatide:

Inosangana nemhando dzepasi rose (FDA, ICH, EU)

Yakaedzwa kuburikidza neHPLC kune yakaderera mazinga ezvinozivikanwa uye zvisingazivikanwe tsvina

Yakagadzirwa pasi peGMP mamiriro ane yakazara process zvinyorwa

Tsigira kugadzirwa kukuru kweR&D