Vardenafil Dihydrochloride kurapa erectile dysfunction 224785-9-5
Chigadzirwa Chinhu
| Zita | Vardenafil dihydrochloride |
| Nhamba | 224785-90-4 |
| Molecular Formula | C23H32n6o4s |
| Sreek inoremerwa | 488.6 |
| Einecs nhamba | 607-088-5 |
| Inonyungudika | 230-235 ° C |
| Density | 1.37 |
| Kuchengetedza mamiriro | Chisimbiso mune chakaoma, chengetedza mu freezer, pasi pe -20 ° C |
| Fomu | Poda |
| Ruvara | Chena |
| Acidity coefficient | (pka) 9.86 ± 0.20 (yakafanotaurwa) |
Synonyms
Vardenafil (SceneptopatentFree); Vardenafilithydrochlorrate (SceneptopatentFree); 2- (2-Ethoxy- 5- (4-ethylpiprezin-1-yl-1-sulfonyl) phenyl)-7-proyl-3-proyl- 3h-er) (1,2-f) trizin-4-imwe; Vardenafilithydrochloridrrate99%; Vardenafilithydrochloridrate Cas # 224785-90-4Fakale; VaMofacturersplyBestquestqualityvardentrochlillydrochlivydrate244785-90-4casno.24785-90-90-4; Fadinaf; 1 - [32- (1,4-Dihydro-5- methyl-4-quoho-7-propyligidizo [5,1-f] [1,2] Triazin-2-yl) -4-Ethoxypherl] -4-EtHyl-pilarahydrochlorydrate
Pharmacological mhedzisiro
Pharmacological chiito
Ichi chinodhaka ndeye phosphodiesererase mhando 5 (PDE5) Inhibitor. Kutonga kweOral kweiyi mushonga kunogona kubatsira zvakabudirira kunaka uye nguva yekurekodha, uye kugadzirisa huwandu hwehupenyu hwepabonde muhupenyu hwevarwere vane erectice dysfunction. Iko kutanga uye kuchengetedza penile erection kwakabatana nekuzorora kweCavernosal masero emutsipa, uye cyclic guanosine monophatephate Ichi chinodhaka chinodzivirira kushomeka kweCGMP uye inhibiting phosphodieseresery type type type type, nekukonzera kuunganidzwa kweCGMP, kuzorora kweiyo Corpus Cavernosum, uye fungidziro ye penis. Kuenzaniswa nePhospodiesereseerase 1, 2, 3, 4, uye 6, uyu mushonga une sarudzo yakakwirira yerudzi 5 Photaphodiesera. Dzimwe data dzinoratidza kuti kusarudza kwayo uye inhibitory mhedzisiro paPhosphodieseresery Type ye5 iri nani pane mamwe mafosphdodiesery mhando 5 inhibitors. Type phosphodieserase inhibitors vashoma.
Mishonga yemishonga uye zvikumbiro
1. Kana ichishandiswa pamwe chete neCyp 3a4 Inhibbitors (yakadai seRitonavir, Saukavir, Erythonale, Erythonale, Erythonale, Erytomy Shanduko dzinoonekwa, musoro, kupisa kumeso, kurwara). Mushonga uyu unofanirwa kudzivirirwa musanganiswa ne ritonavir uye undinavir. Kana ichishandiswa mubatanidzwa neErythromycin, Ketoconalcule, uye ITRACONZOLE, iyo SEPER SECE yezvinodhaka izvi hazvifanirwe kupfuura 5 mg, uye dosi reKetoconale uye ITRACONZOLE haifanirwe kupfuura 200 mg.
2. Varwere vanotora nitrates kana kugashira nitric oxide muridzi wekurapa anofanira kudzivisa kushandisa iyi mushonga musanganiswa. Maitiro ayo echiito ndechekuwedzera kuwedzera iyoKusvinura kweCGMm, zvichikonzera kusimudzira artirtensive mhedzisiro uye kuwedzera moyo chiyero. Kana ichishandiswa pamwe chete ne α-recptor blockers, inogona kusimudzira iyo antiypertgency mhedzisiro uye kutungamira kune hypotension. Naizvozvo, kushandiswa kwemushonga uyu kunorambidzwa kune avo vari kushandisa α-Receptor blockers. Kudya kwemafuta-epakati (30% yemafuta calories pane iyo pharmacokinetics yeimwe dhizaini yeiyi mushonga uye kuderedza kushamisika kweropa kweiyi mishonga iri pamusoro pegumi neshanu.
Pharmacokinetics
Zvinoshambwa mushure mekutonga kwemuromo, iyo yakasarudzika bhizimusi yemuromo wechipfupi ndeye 15%, uye iyo Avhareji nguva yekuPeak ndeye 1H (0.5-2h). Oral Solution 10MG kana 20mg, avhareji nguva yePeak's 0.9h uye avhareji Peak Plasma Constenration is 9μg / L, zvichiteerana, uye nguva yekuroora inosvika 1h. Iyo protein inosunga mwero weiyi mushonga ndeye 95%. 1.5H mushure meimwe kamwe kamwe mg mg, iyo mishonga yemushonga mumabambo ndeye 0.00018% yeiyo dosi. Mushonga unonyanya kuve metabolized mune chiropa ne cytochrome p450 (cyp) 3a4, uye chidiki chidiki chakanyorwa naCyp 3A5 uye Cyp 2c9 isoenymes. Iyo hombe metabolite ndeye m1 yakagadzirwa neyakagadziriswa yePiperazine chimiro chemushonga uyu. M1 zvakare ine mhedzisiro yekuvhiringidza phosphodieseraesterase 5 (anenge 7% yehuwandu hwekubudirira), uye kuiswa kweropa kwaro kunenge makumi maviri neshanu muzana eropa revabereki. , uye inogona kuenderera mberi metabolized. Mitero yekunyanyisa yemishonga yemishonga muchimiro che metabolites mumarara uye urini inenge 91% kusvika 95% uye 2% kusvika 6%, zvichiteerana. Iyo yakazara clearance late ndeye 56 l paawa, nehafu-yehupenyu hwemubereki compand uye m1 ivo vaviri vanenge 4 kusvika maawa mana kusvika mashanu kusvika mashanu.
