Atosiban Acetate Inoshandiswa kune Anti Premature Birth
Product Detail
| Zita | Atosiban |
| CAS nhamba | 90779-69-4 |
| Molecular formula | C43H67N11O12S2 |
| Molecular uremu | 994.19 |
| Nhamba yeEINECS | 806-815-5 |
| Boiling point | 1469.0±65.0 °C (Zvakafanotaurwa) |
| Density | 1.254±0.06 g/cm3(Zvakafanotaurwa) |
| Kuchengetedza mamiriro | -20°C |
| Solubility | H2O:≤100 mg/mL |
Tsanangudzo
Atosiban acetate is disulfide-bonded cyclic polypeptide ine 9 amino acids. Imodified oxytocin molecule panzvimbo 1, 2, 4 uye 8. Iyo N-terminus ye peptide ndeye 3-mercaptopropionic acid (thiol uye The sulfhydryl boka re [Cys] 6 rinoumba disulfide bond), C-terminal iri muchimiro che amide, yechipiri amino acid iri paD-modified, Et-terminal, 2, D-terminal. uye atosiban acetate inoshandiswa mumishonga sevhiniga Inowanikwa nenzira yeasidhi munyu, inowanzonzi atosiban acetate.
Application
Atosiban is oxytocin uye vasopressin V1A yakasanganiswa receptor antagonist, iyo oxytocin receptor yakafanana neiyo vasopressin V1A receptor. Kana iyo oxytocin receptor yakavharwa, oxytocin inogona kuramba ichishanda kuburikidza neV1A receptor, saka zvakakosha kuvhara pamusoro apa nzira mbiri dzekugamuchira panguva imwe chete, uye kupesana kumwe chete kwechigadziro chimwe chete kunogona kuvharidzira uterine contraction. Ichi zvakare chimwe chezvikonzero zvikuru nei β-receptor agonists, calcium channel blockers uye prostaglandin synthase inhibitors isingakwanise kuvharisa uterine contractions.
Mhedzisiro
Atosiban inobatanidza receptor antagonist ye oxytocin uye vasopressin V1A, chimiro chayo chemakemikari chakafanana nechoviri, uye ine hukama hwepamusoro kune vanogamuchira, uye inokwikwidzana neoxytocin uye vasopressin V1A receptors, nokudaro ichivhara nzira yekuita ye oxytocin uye vasopressin uye kuderedza uterine contractions.
