Zita | Eptifibatide |
CAS nhamba | 188627-80-7 |
Molecular formula | C35H49N11O9S2 |
Molecular uremu | 831.96 |
Nhamba yeEINECS | 641-366-7 |
Density | 1.60±0.1 g/cm3(Zvakafanotaurwa) |
Kuchengetedza mamiriro | Yakavharwa pakaoma, chengeta mufiriji, pasi pe -15°C |
Eptifibatideacetatesalt;Eptifibatide,MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2,MPAHARGDWPC-NH2,>99%;MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2;INTEGRELIN;Eptifibatide;N6- (Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl-L-lysylglycyl-La-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide;MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2) (DISULFIDEBRIDGE,MPA1-CYS6).
Etifibatide (integrilin) inoveli polypeptide platelet glycoprotein IIb/IIIa receptor antagonist, iyo inhibits platelet aggregation uye thrombosis nekudzivisa yekupedzisira yakajairika nzira yeplatelet aggregation.Kana ichienzaniswa nemonoclonal antibody abciximab, eptifibatide ine yakasimba, yakananga uye yakananga inosunga kuGPIIb/IIIa nekuda kwekuvapo kweimwe inochengetedza amino acid inotsiva — lysine kutsiva arginine.Nokudaro, inofanira kuva nemigumisiro yakanaka yekurapa mukupindira kwekurapa kweacute coronary syndrome.Platelet glycoprotein IIb/IIIa receptor antagonist zvinodhaka zvakagadzirwa zvakanyanya, uye parizvino kune marudzi matatu egadziriro anogona kushandiswa mumakiriniki pasi rese, abciximab, eptifibatide uye tirofiban.)Pane ruzivo rushoma mukushandiswa kweplatelet glycoprotein GPIIb/IIIa receptor antagonists muChina, uye zvinodhaka zviripo zvakare zvishoma.Mushonga mumwe chete, tirofiban hydrochloride, uri pamusika.Nokudaro, itsva platelet glycoprotein IIb yakagadzirwa./IIIa receptor antagonists zvakakosha.Domestic eptifibatide chigadzirwa chekutevedzera chinogadzirwa neChengdu Sino Biological Products Co., Ltd.
Kurongeka kweAntiplatelet Aggregation Drugs
Antiplatelet aggregation zvinodhaka zvinogona kukamurwa zvakaenzana muzvikamu zvitatu: 1. Cyclooxygenase-1 (COX-1) inhibitors, zvakadai se aspirin.2. Inhibit platelet aggregation inokonzerwa neadenosine diphosphate (ADP), yakadai se clopidogrel, prasugrel, cangrelor, ticagrelor, etc. 3. Platelet glycoprotein Ⅱb/Ⅲa receptor antagonists, akadai abciximab, eptifibatide, etc. In tirofi, etc. prostaglandin EP3 receptor inhibitors, zvichangobva kugadzirwa zvemakemikari zvikamu uye zvinobudirira zvinotorwa kubva muchinyakare Chinese mushonga.