Semaglutide yeRudzi 2 Chirwere cheshuga
Product Detail
| Zita | Semaglutide |
| CAS nhamba | 910463-68-2 |
| Molecular formula | C187H291N45O59 |
| Molecular uremu | 4113.57754 |
| Nhamba yeEINECS | 203-405-2 |
Mashoko anoreva zvakafanana
Sermaglutide; Semaglutide fandachem; Semaglutide tsvina; Sermaglutide USP/EP; semaglutide; Sermaglutide CAS 910463 68 2; Ozempic,
Tsanangudzo
Semaglutide chizvarwa chitsva cheGLP-1 (glucagon-like peptide-1) analogs, uye semaglutide inguva yakareba-yekuita dosage fomu yakagadziridzwa yakavakirwa pane yakakosha chimiro che liraglutide, ine mhedzisiro irinani mukurapa kwerudzi rwechipiri chirwere cheshuga. Novo Nordisk yakapedza 6 Phase IIIa zvidzidzo zve semaglutide injection, uye yakatumira mushonga mutsva wekunyoresa mushonga we semaglutide vhiki nevhiki jekiseni ku US Food and Drug Administration (FDA) musi waDecember 5, 2016. A Marketing Authorization Application (MAA) yakatumirwawo kuEuropean Medicines Agency (EMA).
Kuenzaniswa ne liraglutide, semaglutide ine rebe aliphatic chain uye yakawedzera hydrophobicity, asi semaglutide inogadziriswa neketani pfupi yePEG, uye hydrophilicity yayo inowedzerwa zvakanyanya. Mushure mekuchinja kwePEG, haigone kungosunga padhuze nealbumin, kuvhara iyo enzymatic hydrolysis saiti yeDPP-4, asi zvakare inoderedza kubuda kwerenal, kurebesa hafu yehupenyu hwehupenyu, uye kuwana mhedzisiro yekutenderera kwenguva refu.
Application
Semaglutide ndeyekureba-kuita dosage fomu yakagadziridzwa yakavakirwa pane yekutanga chimiro che liraglutide, iyo inoshanda zvakanyanya mukurapa rudzi rwe2 chirwere cheshuga.
Bioactivity
Semaglutide (Rybelsus, Ozempic, NN9535, OG217SC, NNC0113-0217) inogara kwenguva refu glucagon-like peptide 1 (GLP-1) analog, agonist yeGLP-1receptor, ine inogona mhando 2 Therapeutic efficacy ye2DM mellitus (TDM mellitus).
Quality System
Kazhinji, hurongwa hwemhando uye vimbiso iri munzvimbo inovhara nhanho yese yekugadzirwa kwechigadzirwa chakapedzwa. Yakakwana kugadzira uye kutonga mashandiro anoitwa zvichiteerana nematanho akabvumidzwa / zvakatemwa. Shanduko yekudzora uye Kutsauka kwekubata system iripo, uye inodiwa ongororo yekuongorora uye kuferefeta kwakaitwa. Matanho akakodzera aripo ekuona kunaka kwechigadzirwa chisati chaburitswa mumusika.
