Linaclotide yeGastrointestinal Disorders 851199-59-2
Product Detail
| Zita | Linaclotide |
| CAS nhamba | 851199-59-2 |
| Molecular formula | C59H79N15O21S6 |
| Molecular uremu | 1526.74 |
Mashoko anoreva zvakafanana
Linacllotide;Linaclotide;LinaelotideAcetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine,L-cysteinyl-L-cysteineyl-L-α-glutamyl-L-tyrosyl -L-cysteineyl-L-cysteineyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteineyl-L-threonylglycyl-L-cysteineyl-,cyclic(1→6),(2→10),(5→13)-tris(disulfide)
Tsanangudzo
Linaclotide, yakagadzirwa peptide chimiro ine gumi nemana amino acids, ine hukama nemhuri inogadzika guanosine peptide uye ndiyo yega FDA-inotenderwa GC-C (guanylate) Cyclase-C) agonist mishonga yekurapa inogumbuka bowel syndrome ne constipation (IBS-C) uye chisingaperi idiopathic constipation vakuru (CIC) mukurasika.
Chemical Properties
Linaclotide ichena kusvika kune-white amorphous powder; zvishoma soluble mumvura uye aqueous sodium chloride mhinduro (0.9%).
Zvinoshanda sei
Linaclotide inonzi guanylate cyclase-C receptor agonist (GCCA) ine zvose visceral analgesic uye endocrine basa. Zvose linaclotide uye metabolite yayo inoshanda inogona kusunga kune guanylate cyclase-C (GC-C) receptor pane luminal surface yediki intestinal epithelium. Mune mhando dzemhuka, linaclotide inoderedza kurwadziwa kwevisceral uye inowedzera gastrointestinal kufambisa kuburikidza nekuita kweGC-C, uye muvanhu, mushonga unowedzerawo colonic transit. Mhedzisiro yeGC-C activation yakawedzera intracellular uye extracellular cGMP (cyclic guanosine monophosphate) concentrations. Extracellular cGMP inogona kuderedza basa remarwadzo tsinga fibers uye kuderedza visceral kurwadziwa mumuenzaniso mhuka. Intracellular cGMP inogona kuwedzera secretion ye chloride uye bicarbonate mudumbu diki nekuita CFTR (cystic fibrosis transmembrane conductance regulator), iyo inozopedzisira yaita kuti kuwedzerwa kwemukati memukati memudumbu kuwedzere uye nekumhanya kwediki intestinal transit.
FAQ
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