Carbetutin kudzivirira Uterine Contraction uye PostPartum Hemorrhage
Chigadzirwa Chinhu
| Zita | Carbetutin |
| Nhamba | 3702555-1 |
| Molecular Formula | C45h69n12s |
| Sreek inoremerwa | 988.17 |
| Einecs nhamba | 253-312-6 |
| Kutenderera chaiko | D -69.0 ° (C = 0.25 mu 1M acetic acid) |
| Boiling Point | 1477.9 × 65.0 ° C (yakafanotaura) |
| Density | 1.218 × 0.06 g / cm3 (yakafanotaura) |
| Mamiriro ekuchengetedza | -15 ° C |
| Fomu | poda |
Synonyms
Butyryl-tyr (ini) -I-gln-asn-cys-cys-leu-leu-gly-nh2, (sulfidebondbetutl-4-ylandecys); Butyryl-tyr (ini) -ile-gln-asn-cys-pro-leu-gly-nh2triflandaerocatealt; (Butyryl1, tyr (me) 2) -1-carbaoxytoxytoc intriflarocacetaalt; (Butyryl1, tyr (me) 2) -Oxytocin; (Butyryl1, tyr (me) 2) -OxytocintrifluoroacTaalt; Carbetutin; CarbetCottifluerocacaeroalt; (2-o-methyltyrosine) -de-amino-1-carbaoxytoxcin
Chiitiko cheBiological
CarbetChini, iyo oxytocin (OT) Analog, ndeye oxytocin Receptor agonist ne ki ye7.1 nm. CarbetCocin ine yakakwira nzvimbo (ki = 1.17 μM) ye chimeric n-terminus yeiyo oxytocin rekodhi. Carbetutin ine mukana wePostplartum Horrrhage Tsvaga. CarbetChin inogona kupinda muropa-brain barrier uye ine antidepressant-sechiitiko nekugadzirisa oxytocin Receptors muCNS.
Basa
Carbetutin iri synthetic long-inoita oxytocin 8-pePtide analog ine agonist zvivakwa, uye maclinical uye mishonga yezvivakwa zvakafanana nezvakafanana neyechisikwa oxytocin oxytocin. SaOxytocin, CarbetChin kubhururuka kune vanogamuchira zvechibereko, zvichikonzera kurwadzisa chibereko chechibereko, kuwedzera kuwanda kwahwo uye kuwedzera uterine toni pahwaro hwekutora kweiyo yekutanga. Oxecuncin Receptor mazinga ari muhuchi akaderera mune isina nhumbu yenyika, kuwedzera panguva yekuzvitakura, uye peak panguva yekushanda. Naizvozvo, CarbetCocin haina mhedzisiro pane isina nhumbu chibereko, asi ine chija chine simba chibvumirano chechibereko chechibereko uye chibereko chitsva chakagadzirwa.
Shandura kudzora
Shanduko dzinodzorwa zvinoenderana nemaitiro. Zvichienderana nekukanganiswa uye njodzi uye kuomarara, shanduko dzinoongororwa sevhoriki, diki uye saiti. Site shanduko ine zvishoma kukanganisa pane kuchengeteka uye mhando yechigadzirwa, uye saka usade mvumo uye ziviso kune mutengi; Shanduko diki dzinokanganisa zvine mwero pakuchengetedza uye mhando yechigadzirwa, uye unoda kuzivisa mutengi; Shanduko huru dzinokanganisa zvakanyanya pakuchengetedza uye mhando yechigadzirwa, uye kuda mvumo nemutengi.
Maererano nemaitiro, shanduko yekudzora inotangwa nekushandura application mune iyo shanduko yekuchinja uye rational yekuchinja kunotsanangurwa. Kuongororwa kunoitwa kunoitwa nekutevera chikumbiro, icho chinoitwa nekushandura kudzora madhipatimendi akakodzera. Zvichakadaro, kudzora kwekuchinja kunoiswa muhuwandu hukuru, huwandu hwehuwandu uye diki diki. Mushure mekuongororwa kwakakodzera pamwe nekugadziriswa, ese mwero wekuchinja kudzora anofanira kubvumidzwa neQA maneja. Iyo shanduko yekuchinja inoitwa mushure mekubvumidzwa maererano neiyo chirongwa. Iyo shanduko yekuchinja inopedzisira yakavharwa mushure mekunge QA inosimbisa shanduko yekuchinja yave yakagadziriswa nenzira kwayo. Kana kubatana nevatengi ziviso, mutengi anofanira kuziviswa nguva nenguva mushure mekuchinja kwekuchinja kwakabvumidzwa
